Negative association between trunk fat, insulin resistance and skeleton in obese women

doi:10.4239/wjd.v4.i2.31

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue 2

This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7364)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-5) series, Tables (1-3) series.

Item

Count

PDF

406

HTML

4355

Figures (1-5)

293

Tables (1-3)

309

Sum=5363

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1192

Download

809

Sum=2001

Apr 15, 2013 (publication date) through Feb 8, 2025

Times Cited of This Article

Times Cited (43)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Diabetes. Apr 15, 2013; 4(2): 31-39
Published online Apr 15, 2013. doi: 10.4239/wjd.v4.i2.31

Table 1 Baseline demographics of the study population (mean ± SD)

Characteristics	n = 340
Mean age (yr)	44.8 ± 14
BMI (kg/m²)	36 ± 5.9
Total cholesterol (mg/dL)	196 ± 41
HDL-cholesterol (mg/dL)	49 ± 11
Triglycerides (mg/dL)	120 ± 68
HOMA-IR	4.7 ± 3
SHBG (nmol/L)	42 ± 58.5
PTH (pg/mL)	45 ± 21
Leptin (nmol/L)	75 ± 30
Vitamin D	20.5 ± 9.8
17β-estradiol	70 ± 54

BMI: Body mass index; HOMA-IR: Homeostasis model assessment of insulin resistance; Vitamin D: 25-hydroxyvitamin D; PTH: Parathyroid hormone; HDL: High-density lipoprotein; SHBG: Sex hormone binding globulin.

Table 2 Biochemical and hormonal characteristics of the study population according to different body mass index

	BMI < 30 kg/m²	BMI 30-35 kg/m²	BMI 35-40 kg/m²	BMI > 40 kg/m²
	(n = 80)	(n = 100)	(n = 80)	(n = 80)
BMI	27 ± 1.2	32.5 ± 1^b	37 ± 1.5^b	44 ± 2^b
Mean age (yr)	46.5 ± 15	45 ± 14	46 ± 13	43 ± 14
Total-cholesterol (mg/dL)	199 ± 54	198 ± 41	204 ± 40	190 ± 32
HDL-cholesterol (mg/dL)	52 ± 13	50 ± 11	50 ± 10	46 ± 10
Triglycerides (mg/dL)	114 ± 79	117 ± 61	130 ± 72	122 ± 68
Fibrinogen (mg/dL)	346 ± 102	341 ± 63	368 ± 85	421 ± 86^b
C-reactive protein (ng/mL)	2 ± 0.9	2.8 ± 0.9	5.0 ± 1.4^b	5.5 ± 2.1^b
HOMA-IR	2.8 ± 0.9	3.1 ± 0.8	5.0 ± 2.6^b	6.4 ± 2.2^b
PTH (pg/mL)	40 ± 15	42 ± 20	46 ± 23	48 ± 19
Vitamin D	26 ± 9	20 ± 10^b	16 ± 8^b	15 ± 10^b

^bP < 0.01 vs BMI < 30 kg/m². BMI: Body mass index; HOMA-IR: Homeostasis model assessment of insulin resistance; Vitamin D: 25-hydroxyvitamin D; PTH: Parathyroid hormone; HDL: High-density lipoprotein.

Table 3 Multivariate analysis showing that vitamin D is the only parameter that is independently associated with trunk fat percentage

Unstandardized coefficients¹			Standardized coefficients¹
Model	B	SE	Beta	t	P value
1 (constant)	52.054	8.498		6.125	0.000
Lumbar BMD	6.570	8.121	0.167	0.809	0.437
Hip BMD	-9.971	7.687	-0.259	-1.029	0.224
Vitamin D	-0.359	0.077	-1.029	-4.666	0.001
Osteocalcin	0.134	0.111	0.255	1.208	0.255
IGF-1	-0.002	0.014	-0.022	-0.114	0.916

¹Dependent variable of trunk fat. IGF-1: Insulin-like growth factor-1; BMD: Bone mineral density.

Citation: Greco EA, Francomano D, Fornari R, Marocco C, Lubrano C, Papa V, Wannenes F, Di Luigi L, Donini LM, Lenzi A, Aversa A, Migliaccio S. Negative association between trunk fat, insulin resistance and skeleton in obese women. World J Diabetes 2013; 4(2): 31-39
URL: https://www.wjgnet.com/1948-9358/full/v4/i2/31.htm
DOI: https://dx.doi.org/10.4239/wjd.v4.i2.31