Comparison between sitagliptin and nateglinide on postprandial lipid levels: The STANDARD study

Table 1 Baseline patient profile and post-treatment data

	Sitagliptin group		Nateglinide group
	Before treatment	After 3 mo of treatment	Before treatment	After 3 mo of treatment
Age (yr)	63.85 ± 12.92	-	66.44 ± 9.02	-
Sex: M/F (n)	15/5	15/5	12/4	12/4
Body weight (kg)	68.79 ± 12.891	69.30 ± 13.18	58.36 ± 8.54	58.75 ± 8.52
Systolic blood pressure (mmHg)	134.3 ± 19.3	126.5 ± 11.1	129.1 ± 13.9	122.7 ± 14.8
Diastolic blood pressure (mmHg)	81.5 ± 12.9	73.3 ± 7.4b	76.9 ± 8.8	74.3 ± 10.2
HbA1c (%)	7.2 ± 0.7	7.0 ± 0.8b	7.2 ± 0.4	6.8 ± 0.5b
Glycated albumin (%)	19.3 ± 3.6	17.7 ± 2.6b	19.9 ± 3.4	18.1 ± 2.8b
1.5-AG (μmol/L)	65.5 ± 45.8	81.6 ± 46.2b	51.0 ± 22.7	69.5 ± 29.3b
Fasting blood glucose (mmol/L)	7.8 ± 1.7	7.3 ± 1.6	8.1 ± 1.0	7.6 ± 1.5
Blood glucose 1 h postprandially (mmol/L)	12.0 ± 3.0	10.6 ± 3.1b	13.6 ± 2.3	11.0 ± 2.8b
Blood glucose 3 h postprandially (mmol/L)	7.6 ± 2.5	6.6 ± 2.0b	7.6 ± 2.5	6.5 ± 1.9a
Apo-B48 AUC (g/L per hour)	2.48 ± 0.11	1.94 ± 0.78a	3.14 ± 0.29	2.29 ± 0.16
Apo-A1 AUC (g/L per hour)	4.64 ± 0.73	4.50 ± 0.76	4.59 ± 0.73	4.67 ± 0.76
Apo-B AUC (g/L per hour)	2.73 ± 0.47	2.91 ± 0.46	2.60 ± 0.46	2.64 ± 0.40
Apo-C3 AUC (g/L per hour)	0.30 ± 0.07	0.28 ± 0.06	0.31 ± 0.11	0.28 ± 0.09
Fasting insulin (pmol/L)	53.3 ± 26.9	58.4 ± 34.4	41.3 ± 29.0	40.4 ± 31.5
Insulin 1 h postprandially (μU/mL)	279.3 ± 115.7	275.1 ± 143.4	230.1 ± 104.2	248.7 ± 112.2
Fasting glucagon (ng/L)	67.2 ± 15.9	66.6 ± 16.0	65.1 ± 16.4	70.1 ± 16.0
Glucagon 1 h postprandially (ng/L)	80.3 ± 17.0	70.3 ± 16.9a	79.0 ± 13.4	81.5 ± 20.6
Fasting triglycerides (mmol/L)	1.26 ± 0.81	1.09 ± 0.61a	1.54 ± 1.44	1.11 ± 0.60

¹This parameter showed a significant between-group difference (P < 0.05) before treatment. Data are shown as the mean ± SD (^aP < 0.05,

^bP < 0.01 vs time curve). Area under the concentration vs time curve (AUC) data were obtained from before to three hours after the test meal. The t test was used for statistical analysis. M: Male; F: Female; 1.5-AG: 1.5-anhydroglucitol; Apo: Apolipoprotein; HbA_1c: Hemoglobin A_1c.