Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes

Table 1 Differential metabolites

No.	Metabolites	tR/minute	m/z	Formula	Mode	HMDB ID	Trend
							Con/Mod	Mod/DLC
1	Eriodictyol	5.652	269.04530	C15H12O6	ESI-	HMDB0005810	↓	↑
2	N-Acetyl-D-galactosamine 4-sulfate	1.307	300.03916	C8H15NO9S	ESI-	HMDB0000781	↑	↑
3	α-ketoglutaric acid	1.481	145.01309	C5H6O5	ESI-	HMDB0000208	↑	↓
4	Palmitic acid	10.254	255.23257	C16H32O2	ESI-	HMDB0000220	↓	↑
5	2,3-Dihydroxybenzoic acid	4.998	153.01833	C7H6O4	ESI-	HMDB0000397	↓	↑
6	L-Ascorbic acid 2-sulfate	1.512	254.98142	C6H8O9S	ESI-	HMDB0060649	↓	↑
7	2-Methylglutaric acid	5.244	145.04955	C6H10O4	ESI-	HMDB0000422	↑	↓
8	Ascorbic acid	2.571	175.02375	C6H8O6	ESI-	HMDB0000044	↓	↑
9	4-Methylvaleric Acid	5.819	231.15956	C6H12O2	ESI-	HMDB0000689	↑	↓
10	Taurolithocholic acid 3-sulfate	5.789	562.24355	C26H45NO8S2	ESI-	HMDB0002580	↓	↑
11	Caffeic acid	5.337	179.03762	C9H8O4	ESI-	HMDB0001964	↓	↑
12	Citramalic acid	4.201	147.03161	C5H8O5	ESI-	HMDB0000426	↓	↑
13	7-Ketolithocholic acid	6.960	389.26952	C24H38O4	ESI-	HMDB0000467	↑	↓
14	Anacardic acid	8.440	347.25888	C22H36O3	ESI-	HMDB0033896	↑	↓
15	Phenylpyruvic acid	5.521	163.03907	C9H8O3	ESI-	HMDB0000205	↑	↓
16	Gamma-Caprolactone	5.150	273.13431	C6H10O2	ESI-	HMDB0003843	↑	↓
17	Syringic acid	3.826	197.04482	C9H10O5	ESI-	HMDB0002085	↓	↑
18	Asp-Phe	5.159	279.09876	C13H16N2O5	ESI-	HMDB0000706	↑	↓
19	Palmitoylcarnitine	8.360	398.32717	C23H45NO4	ESI-	HMDB0240774	↓	↑
20	L-Kynurenine	3.964	207.07683	C10H12N2O3	ESI-	HMDB0000684	↑	↓
21	2,3,4-Trihydroxybenzoic acid	4.767	169.01344	C7H6O5	ESI-	HMDB0059964	↓	↑
22	7-Methylxanthine	2.950	165.04090	C6H6N4O2	ESI-	HMDB0001991	↑	↓
23	N-Acetyl-L-histidine	1.349	196.07196	C8H11N3O3	ESI-	HMDB0032055	↑	↓
24	D-Glucosamine 6-phosphate	1.287	258.03813	C6H14NO8P	ESI-	HMDB0001254	↓	↑
25	Allantoin	1.297	157.03556	C4H6N4O3	ESI-	HMDB0000462	↓	↑
26	LPC 20: 3	8.96	590.34664	C28H52NO7P	ESI-	-	↓	↑
27	ADP-ribose	1.390	560.07848	C15H21N5O13P2	ESI-	HMDB0249529	↓	↑
28	Creatine	1.321	132.07689	C4H9N3O2	ESI+	HMDB0000064	↓	↑
29	N6,N6,N6-Trimethyl-L-lysine	1.180	189.16000	C9H20N2O2	ESI+	HMDB0001325	↓	↑
30	Propionylcarnitine	3.040	218.13907	C10H19NO4	ESI+	HMDB0000824	↓	↑
31	Biotin	5.387	245.09590	C10H16N2O3S	ESI+	HMDB0000030	↑	↓
32	Argininosuccinic acid	1.283	291.12971	C10H18N4O6	ESI+	HMDB0000052	↓	↑
33	Glycitein	5.804	285.07588	C16H12O5	ESI+	HMDB0005781	↓	↑
34	L-Saccharopine	1.248	277.13934	C11H20N2O6	ESI+	HMDB0000279	↓	↑
35	Histidine	1.376	139.05028	C6H9N3O2	ESI+	HMDB0000177	↑	↓
36	3-(3,4-dihydroxyphenyl) propanoic acid	5.224	165.05499	C9H10O4	ESI+	HMDB0000423	↓	↑
37	Glu-Thr	1.371	114.06653	C9H16N2O6	ESI+	HMDB0028829	↓	↑
38	N-(5-Aminopentyl) acetamide	1.743	145.13362	C7H16N2O	ESI+	HMDB0002284	↓	↑
39	Mycophenolic acid	1.242	321.12973	C17H20O6	ESI+	HMDB0015159	↓	↑
40	3-Methoxytyramine	5.595	150.09125	C9H13NO2	ESI+	HMDB0000022	↑	↓
41	Ornithine	1.140	116.07090	C5H12N2O2	ESI+	HMDB0000214	↑	↓
42	Muscone	9.526	239.23704	C16H30O	ESI+	HMDB0034181	↓	↑
43	Ethyl oleate	9.587	311.29466	C20H38O2	ESI+	HMDB0034451	↓	↑
44	4-Guanidinobutanoic acid	5.254	146.09272	C5H11N3O2	ESI+	HMDB0003464	↑	↓
45	Arachidonic acid methyl ester	6.421	319.26285	C21H34O2	ESI+	HMDB0062594	↑	↓
46	Citrulline	1.890	176.10324	C6H13N3O3	ESI+	HMDB0250742	↑	↓
47	Xanthurenic acid	5.081	206.04522	C10H7NO4	ESI+	HMDB0000881	↑	↓
48	D-Alanyl-D-alanine	5.737	161.09236	C6H12N2O3	ESI+	HMDB0003459	↓	↑
49	Leu-Pro	3.991	211.14435	C11H20N2O3	ESI+	HMDB0011175	↓	↑
50	gamma-Glutamyltyrosine	4.943	311.12415	C14H18N2O6	ESI+	HMDB0011741	↑	↓
51	Xanthine	2.026	153.04077	C5H4N4O2	ESI+	HMDB0000292	↑	↓
52	dAMP	1.990	332.07433	C10H14N5O6P	ESI+	HMDB0000905	↓	↑
53	Uracil	1.681	113.03489	C4H4N2O2	ESI+	HMDB0000300	↑	↓
54	Urocanic acid	1.378	139.05026	C6H6N2O2	ESI+	HMDB0000301	↑	↓
55	22(S)-Hydroxycholesterol	9.474	403.3570	C27H46O2	ESI+	-	↓	↑
56	PC O-20:3	8.945	546.35561	C28H52NO7P	ESI+	-	↓	↑
57	PC O-18:1	9.181	522.35554	C26H52NO7P	ESI+	-	↓	↑

DLC: Dimocarpus longan Lour leaf components; Con: Control group; Mod: The model group.