MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B

doi:10.4239/wjd.v16.i4.93630

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Apr 15, 2025 (publication date) through Feb 28, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Apr 15, 2025; 16(4): 93630
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.93630

Table 1 Detailed information on antibodies

Molecular	Molecular weight	Source	Reactive species	Company
DNMT3A (ab188470)	102 kDa	Rabbit	Human/mouse/rat	Abcam
DNMT3B (L2011188)	28 kDa	Mouse	Mouse	US Biological
α-SMA (ab205719)	42 kDa	Mouse	Mouse/rat/human/African green monkey	Abcam
Collagen I (ab270993)	139 Da	Rabbit	Mouse/rat	Abcam
Fibronectin (ab268020)	262 kDa	Rabbit	Human/mouse/rat	Abcam
Wnt3a (ab219412)	39 kDa	Rabbit	Human/mouse/rat	Abcam
β-catenin (D10A8)	92 kDa	Rabbit	Human/mouse/rat/monkey	Cell signaling technology
JAK2 (D2E12)	125 kDa	Rabbit	Human/mouse/rat/monkey	Cell signaling technology
STAT3 (124H6)	79 kDa/86 kDa	Mouse	Human/mouse/rat/monkey	Cell signaling technology
Tubulin (ab7291)	55 kDa	Mouse	Mouse/rat/human	Abcam
GAPDH (ab8245S)	37 kDa	Mouse	Mouse/rat/human	Abcam

DNMT3A: DNA methyltransferase 3A; DNMT3B: DNA methyltransferase 3B; JAK 2: Janus kinase 2; STAT3: Signal transducer and activator of transcription 3; α-SMA: Alpha smooth muscle actin.

Table 2 Primer sequences

Primer	Sequence (5’ to 3’)
MiR-29a-3p-RT	GTCGTATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACTAACCG
MiR-29a-3p-F	CGCGTAGCACCATCTGAAAT
MiR-29a-3p-R	AGTGCAGGGTCCGAGGTATT
U6-F	AGAGAAGATTAGCATGGCCCCTG
U6-R	AGTGCAGGGTCCGAGGTATT

Citation: Yang Y, Chen Y, Tang JY, Chen J, Li GQ, Feng B, Mu J. MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B. World J Diabetes 2025; 16(4): 93630
URL: https://www.wjgnet.com/1948-9358/full/v16/i4/93630.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i4.93630