Bone marrow-derived mesenchymal stem cell-derived exosome-loaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

Table 1 The sequences of primers used in the experiments

Name		Sequence (5’-3’)
miR-129-5p	Forward	CGGCGGTTTGCGGTCTGGGCT
	Reverse	CAACTGGAGGACTCCATGCTG
U6	Forward	GATCTCGGAAGCTAAGCAGG
	Reverse	TGGTGCAGGGAGGTAT
mouseHMGB1	Forward	ATCCCAATGCACCCAAGAGG
	Reverse	CAATGGACAGGCCAGGATGT
mouseGAPDH	Forward	AGGTCGGTGTGAACGGATTTG
	Reverse	TGTAGACCATGTAGTTGAGGTC
mouseIL-6	Forward	GGCCCTTGCTTTCTCTTCG
	Reverse	ATAATAAAGTTTTGATTATGT
mouseTNF-α	Forward	GACCCTCACACTCAGATCATCTTCT
	Reverse	CCTCCACTTGGTGGTTTGCT

HMGB1: High-mobility group box 1; IL: Interleukin; TNF: Tumor necrosis factor.

Table 2 Neurological function rating scale

	0	1	2	3	4
Body symmetry	Normal	Slight asymmetry	Moderate asymmetry	Significant asymmetry	Extreme asymmetry
Gait	Normal	Stiffness and rigidity	Limping	Trembling, stumbling, falling	No walking
Climbing	Normal	Stressful climbing and weakness of limbs	Grasping the slope without sliding or climbing	Sliding down a slope, falling uncontrollably	Immediately slides and fallsun control-lably
Turning behavior	No appearance	Tendency to turn to one side	Occasional tendency to turn to one side	Constant tendency to turn to one side	Rotation, swaying, immobility
Anterior symmetry	Normal	Mild asymmetry	Significant asymmetry	Clearly asymmetry	Slight asymmetry, immobility of body limbs
Forced circling	No appearance	Tendency to turn to one side	-	-	-