Lower extremity amputations and long-term outcomes in diabetic foot ulcers: A systematic review

Table 1 Follow-up, nature, and presence of standardisation in selected studies

Ref.	Number of patients lost to follow up (5)	Nature of study	Standardisation for comorbidities
Chu et al[12]	17 (6.9)	Prospective	Standardised
Larrson et al[7]	0	Prospective	Not standardised
Schleiffer et al[23]	0	Prospective	Standardised
Faglia et al[20]	0	Prospective	Standardised
Van Damme et al[13]	0	Prospective	Standardised
Goldner et al[5]	NS	Prospective	Standardised
Morbach et al[16]	0	Prospective	Standardised
Ghanassia et al[8]	5 (5)	Prospective	Standardised
Skoutas et al[10]	0	Prospective	Standardised
Adler et al[24]	155 (2)	Prospective	Standardised
Ohsawa et al[25]	0	Prospective	Standardised
Izumi et al[9]	N/A	Retrospective	Standardised
Murdoch et al[6]	N/A	Retrospective	Standardised
Uzzaman et al[26]	N/A	Retrospective	Standardised
Acar et al[11]	N/A	Retrospective	Standardised
Nerone et al[17]	N/A	Retrospective	Standardised
Aulivola et al[27]	N/A	Retrospective	Not standardised
Jeyaraman et al[18]	N/A	Retrospective	Standardised
Jeyaraman et al[21]	N/A	Retrospective	Standardised
Thorud et al[15]	N/A	Meta-analyses	Standardised
Albers et al[28]	N/A	Meta-analyses	Standardised
Borkosky et al[14]	N/A	Systematic Review	Standardised

NS: Not specified; N/A: Not applicable.

Table 2 Re-amputation at 1, 3 and 5 years in patients who previously had had a lower extremity amputation due to diabetes foot ulcer

Ref.	Year	n	Re-amputation, %
			1 yr	3 yr	5 yr
Acar et al[11]	2017	132	NS	22	N/A
Uzzaman et al[26]	2016	79	NS	NS	13.9
Chu et al[12]	2014	245	12.5	22.3	47.1
Skoutas et al[10]	2009	121	21.5	N/A	N/A
Ghanassia et al[8]	2008	39	NS	NS	55.6
Izumi et al[9]	2006	277	26.7	48.3	60.7
Faglia et al[20]	2001	80	0	0	0
Murdoch et al[6]	1997	90	NS	NS	60
Hosch et al[29]	1997	35	63	N/A	N/A
Weighted, mean ± SD			20.14 ± 3.55	29.63 ± 8.35	45.72 ± 9.09

NS: Not specified; N/A: Not applicable.

Table 3 Mortality at 1, 3 and 5 years in patients who previously had had a lower extremity amputation due to diabetes foot ulcer

Ref.	Year	n	Mean age	Male, %	Mortality, %
					1 yr	3 yr	5 yr
López-Valverde et al[30]	2018	203	72	78	9.4	27.2	44.5
Uzzaman et al[26]	2016	79	75	64.5	15.6	25	27
Chu et al[12]	2014	245	69.27	53	5.8	15.1	32.7
Morbach et al[16]	2012	38	68.8	58.7	15.4	33.1	45.8
Ghanassia et al[8]	2008	39	63.8	69.7	12	35	44
Faglia et al[20]	2001	80	63.4	73	33.3	51.9	74.1
Larrson et al[7]	1998	187	72	56	15	38	68
Apelqvist et al[4]	1993	123	70	55	20	41	73
Weighted, mean ± SD					13.62 ± 0.92	30.25 ± 2.12	50.55 ± 4.13