Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells

Table 1 Significantly enriched Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway terms of differentially expressed long noncoding RNAs

Category	Term	–log10 (P value)
GOTERM_BP	G-protein coupled receptor signaling pathway	3.23
GOTERM_BP	Inflammatory response	2.73
GOTERM_BP	Neuropeptide signaling pathway	2.59
GOTERM_BP	Positive regulation of cell proliferation	2.55
GOTERM_BP	Detection of temperature stimulus involved	2.53
GOTERM_BP	Positive regulation of ERK1 and ERK2 cascade	2.32
GOTERM_BP	Regulation of blood coagulation	2.26
GOTERM_BP	Midgut development	2.26
GOTERM_BP	Phospholipase G-protein coupled receptor signaling pathway	2.26
GOTERM_BP	Nervous system development	2.19
GOTERM_CC	Integral component of plasma membrane	3.35
GOTERM_CC	Extracellular space	3.14
GOTERM_CC	Extracellular region	2.46
GOTERM_CC	External side of plasma membrane	1.67
GOTERM_CC	Secretory granule	1.60
GOTERM_CC	Plasma membrane	1.46
GOTERM_CC	Integral component of membrane	1.22
GOTERM_CC	Microvillus	1.19
GOTERM_CC	Dendrite	1.17
GOTERM_CC	Caveola	1.04
GOTERM_MF	G-protein alpha-subunit binding	2.96
GOTERM_MF	Growth factor activity	1.93
GOTERM_MF	G-protein coupled receptor activity	1.39
GOTERM_MF	Serotonin binding	1.18
GOTERM_MF	Cytokine activity	1.13
GOTERM_MF	L-amino acid transmembrane transporter activity	1.02
GOTERM_MF	G-protein coupled peptide receptor activity	1.02
GOTERM_MF	Olfactory receptor activity	1.01
KEGG PATHWAY	Neuroactive ligand-receptor interaction	1.97
KEGG PATHWAY	Calcium signaling pathway	1.51

Table 2 Common molecular targets of glucagon-like peptide-1 and geniposide from SwissTargetPrediction

Common name	Uniprot ID	Target class
Ace	P47820	Ligand-gated ion channel
Adrb3	P26255	Electrochemical transporter
Agtr1	P25095	Family A G protein-coupled receptor
Agtr1b	P29089	Family A G protein-coupled receptor
App	P08592	Secreted protein
Ca2	P27139	Transferase
Chrna7	Q05941	Hydrolase
Ctsk	O35186	Protease
Ednra	P26684	Enzyme
Ednrb	P21451	Family A G protein-coupled receptor
Hdac1	Q4QQW4	Nuclear receptor
Hmgcr	P51639	Enzyme
Mme	P07861	Enzyme
Oprm1	P33535	Family A G protein-coupled receptor
Pparg	O88275	Nuclear receptor
Prkcg	P63319	Structural protein
Ptgs2	P35355	Family A G protein-coupled receptor
Pygl	P09811	Enzyme
Ren1	P08424	Family A G protein-coupled receptor
Slc6a3	P23977	Electrochemical transporter
Tert	Q673L6	Enzyme
Trpv1	O35433	Voltage-gated ion channel

Table 3 Long noncoding RNAs co-expressed with Pomc, Htr2a, and Agtr1a

Accession No.	Fold change	Pearson coefficient
		Pomc_R	Htr2a_R	Agtr1a_R
NONRATT002662	0.1959	0.9090	0.9755	0.9817
NONRATT024273	0.2602	0.9154	0.9771	0.9545
NONRATT012943	0.3411	0.9204	0.9472	0.9517
NONRATT027738	0.3471	0.9406	0.9727	0.9301
NONRATT005090	0.3603	0.9784	0.9478	0.9135
NONRATT012881	0.4662	0.9546	0.9744	0.9543
NONRATT005619	0.5677	0.9246	0.9325	0.9156
NONRATT019513	0.5766	0.9175	0.9455	0.9540
NONRATT027888	0.6136	0.9008	0.9814	0.9888
NONRATT006762	0.6532	0.9681	0.9586	0.9307
NONRATT030038	0.6647	0.9150	0.9693	0.9579
NONRATT018166	1.5013	-0.9275	-0.9451	-0.9448
NONRATT009725	1.5275	-0.9611	-0.9396	-0.9083
NONRATT029435	1.5916	-0.9026	-0.9437	-0.9207
NONRATT011324	1.6616	-0.9657	-0.9531	-0.9340
NONRATT028536	1.7515	-0.9181	-0.9419	-0.9257
NONRATT022232	1.8792	-0.9313	-0.9539	-0.9562
NONRATT008800	1.9416	-0.9273	-0.9485	-0.9313
NONRATT019269	2.1925	-0.9377	-0.9152	-0.9126
NONRATT011068	2.4783	-0.9561	-0.9828	-0.9551
NONRATT018149	3.9636	-0.9114	-0.9435	-0.9337

Pearson coefficient < 0 means a negative correlation, and Pearson coefficient > 0 means a positive correlation.