Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

doi:10.4239/wjd.v11.i7.309

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World Journal of Diabetes

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World J Diabetes. Jul 15, 2020; 11(7): 309-321
Published online Jul 15, 2020. doi: 10.4239/wjd.v11.i7.309

Table 1 The median of the parameters and the correlation between neuropathy clinical scores and biochemical parameters, visfatin, and oxidative stress biomarkers

	SPNSQ score, 5.66 ± 3.64	MNSI q, 4.5 ± 2.28	MNSI exam, 2.42 ± 1.99
Glucose, mg/dL, 154.0 ± 57.5	P = 0.099, r = 0.084	P = 0.110, r = 0.081	P = 0.110, r = 0.081
HbA1c, 7.68 ± 1.52	P = 0.099, r = 0.084	P = 0.062, r = 0.094	^bP < 0.01, r = 0.170
Creatinine, mg/dL, 0.81 ± 0.13	P = 0.017, r = -0.121	P = 0.053, r = -0.098	P = 0.143, r = 0.074
ALT, U/L, 22.3 ± 12.8	P = 0.177, r = 0.000	P = 0.518, r = 0.033	P = 0.585, r = 0.028
AST, U/L, 18.6 ± 7.8	P = 0.587, r = 0.028	P = 0.676, r = 0.021	P = 0.810, r = -0.012
LDL cholesterol, mg/dL, 118.12 ± 28.00	P = 0.077, r = 0.090	P = 0.151, r = 0.073	P = 0.868, r = 0.008
Triglycerides, mg/dL, 160.3 ± 85.0	P =0.123, r = 0.078	P = 0.355, r = 0.047	P = 0.994, r = 0.000
Vitamin B12, pg/mL, 425.5 ± 32.0	^aP < 0.05, r = 0.132	P = 0.062, r = 0.095	P = 0.049, r = 0.100
Visfatin, pg/mL, 19.34 ± 8.07	P = 0.579, r = 0.028	P = 0.330, r = 0.049	^aP < 0.05, r = 0.122
TOS, μmol H₂O₂/L, 12.91 ± 1.92	P = 0.417, r = 0.041	P = 0.340, r = 0.048	^aP < 0.05, r = 0.155
TAS, mmol Trolox Eq./L, 0.87 ± 0.14	P = 0.385, r = 0.044	P = 0.160, r = -0.071	^aP < 0.05, r = -0.127
OSI (Arbitrary units), r = 0.20, 15.29 ± 4.12	P = 0.283, r = 0.054	P = 0.170, r = 0,069	^bP < 0.01, P = 0.000
Total thiol, mmol/L, 0.51 ± 0.05	P = 0.070, r = -0.092	P = 0.053, r = -0.098	P = 0.251, r = -0.05
Native thiol, mmol/L, 0.35 ± 0.05	P = 0.822, r = 0.011	P = 0.903, r = -0.006	P = 0.864, r = -0.009
Thiol-disulfide, mmol/L, 0.08 ± 0.03	P = 0.059, r = -0.096	P = 0.069, r = -0.092	P = 0.270, r = -0.056

^aP < 0.05,

^bP < 0.01. SPNSQ: Subjective Peripheral Neuropathy Screen Questionnaire; MNSI q: Michigan Neuropathy Screening Instrument questionnaire; MNSI exam: Michigan Neuropathy Screening Instrument examination; HbA1c: Glycosylated hemoglobin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TOS: Total oxidant status; TAS: Total antioxidant status; OSI: Oxidative stress index; LDL: Low density lipoprotein.

Table 2 The correlation between the Michigan Neuropathy Screening Instrument neuropathy scores and visfatin with oxidative stress biomarkers

	MNSI q < 7	MNSI q ≥ 7	P value	MNSI exam < 2.5	MNSI exam ≥ 2.5	P value
Visfatin	19.15 ± 7.93	20.08 ± 8.62	0.357	18.32 ± 6.97	20.64 ± 9.16	< 0.01
TOS	12.88 ± 1.90	13.04 ± 2.01	0.486	12.64 ± 1.63	13.26 ± 2.20	< 0.05
TAS	0.88 ± 0.14	0.85 ± 0.13	0.102	0.88 ± 0.12	0.85 ± 0.15	< 0.05
OSI	15.14 ± 4.09	15.84 ± 4.23	0.178	14.62 ± 3.45	16.64 ± 4.72	< 0.01
Total thiol	0.51 ± 0.00	0.51 ± 0.05	0.385	0.52 ± 0.05	0.51 ± 0.05	0.228
Native thiol	0.35 ± 0.05	0.34 ± 0.06	0.570	0.35 ± 0.05	0.35 ± 0.06	0.638
Thiol-disulfide	0.08 ± 0.03	0.08 ± 0.03	0.850	0.08 ± 0.03	0.08 ± 0.03	0.399

MNSI q: Michigan Neuropathy Screening Instrument questionnaire; MNSI exam: Michigan Neuropathy Screening Instrument examination; TOS: Total oxidant status; TAS: Total antioxidant status; OSI: Oxidative stress index.

Table 3 The median of the parameters and the correlation between glucose, serum oxidative stress biomarkers, and visfatin with thiol groups

	Visfatin, 19.34 ± 8.07	Total thiol, 0.51 ± 0.05	Native thiol, 0.35 ± 0.05	Thiol-disulfide, 0.08 ± 0.03
Glucose, 154.0 ± 57.5	P < 0.05, r = 0.537	P < 0.01, r = -0.204¹	P < 0.05¹, r = -0.452¹	P < 0.01, r = 0.206
HbA1c, 7.68 ± 1.52	P < 0.05, r = 0.753	P < 0.01, r = -0.351¹	P < 0.05¹, r = -0.597¹	P < 0.01, r = 0.194
TOS, 12.91 ± 1.92	P < 0.05, r = 0.407	P < 0.05, r = -0.236¹	P < 0.05¹, r = -0.352¹	P < 0.01, r = 0.094
TAS, 0.87 ± 0.14	P < 0.05, r = -0.499¹	P < 0.01, r = 0.243	P < 0.05, r = 0.408	P < 0.01, r = -0.134¹
OSI, 15.29 ± 4.12	P < 0.05, r = 0.587	P < 0.05, r = -0.322¹	P < 0.05¹, r = -0.485¹	P < 0.01, r = 0.132
Visfatin		P < 0.01, r = -0.338¹	P < 0.01¹, r = -0.448¹	P = 0.092

¹Correlations with negative directions are presented. HbA1c: Glycosylated hemoglobin; TOS: Total oxidant status; TAS: Total antioxidant status; OSI: Oxidative stress index.

Citation: Buyukaydin B, Guler EM, Karaaslan T, Olgac A, Zorlu M, Kiskac M, Kocyigit A. Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers. World J Diabetes 2020; 11(7): 309-321
URL: https://www.wjgnet.com/1948-9358/full/v11/i7/309.htm
DOI: https://dx.doi.org/10.4239/wjd.v11.i7.309