Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?

Table 1 Baseline characteristics of the two groups

Baseline characteristics	Gastric bypass	Sleeve gastrectomy
Patient numbers	23	19
Male	6	14
Female	17	5
Age (yr)	44.7 ± 9.7	40.1± 9.1
Duration of type 2 diabetes mellitus (yr)	4.0 ± 2.7	2.6 ± 2.8

Table 2 Body mass index, hemoglobin A1c, fasting blood sugar, matrix metalloproteinas-2, -7, and -9 levels at baseline, 3 mo, 12 mo, and 24 mo after gastric bypass

	BMI (kg/m2)		Waist circumference (cm)		HbA1c (%)		FBS (mg/dL)		MMP-2 (ng/mL)		MMP-7 (ng/mL)		MMP-9 (ng/mL)
	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD
M0	30.3	3.4	103.2	10.3	9.2	1.5	171.6	65.0	9.22	1.9	2.5	1.2	21.7	22.3
M3	26.0	2.8	90.4	8.0	7.1	1.6	127.0	46.7	9.28	2.0	2.1	1.1	18.8	12.8
M12	24.2	2.2	82.3	5.3	6.5	1.2	114.1	31.1	10.65	4.3	2.5	1.2	20.6	16.2
M24	24.4	2.4	84.2	7.1	6.7	1.41	117.7	37.5	10.59	3.5	1.5	1.2	19.1	22.4
P	< 0.0011		< 0.0011		< 0.0011		< 0.0011		0.107		0.258		0.466

SD: Standard deviation; BMI: Body mass index; HbA1c: Hemoglobin A1c; FBS: Fasting blood sugar; MMP: Matrix metalloproteinases; M0: The baseline prior to surgery; M3: 3 mo postoperatively; M12: 12 mo postoperatively; M24: 24 mo postoperatively.

¹Statistically significant.

Table 3 Body mass index, hemoglobin A1c, fasting blood sugar, matrix metalloproteinas-2, -7, and -9 levels at baseline, 3 mo, 12 mo, and 24 mo after sleeve gastrectomy

	BMI (kg/m2)		Waist circumference (cm)		HbA1c (%)		FBS (mg/dL)		MMP-2 (pg/mL)		MMP-7 (pg/mL)		MMP-9 (pg/mL)
	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD	mean	SD
M0	36.2	5.1	109.4	10.5	7.9	1.7	138.3	55.6	15.4	10.8	2.3	1.3	12.1	9.4
M3	30.6	4.6	92.5	9.9	5.9	0.5	91.0	2.2	16.3	12.9	2.1	1.2	16.4	12.2
M12	26.8	4.4	87.1	12.7	5.7	0.5	90.6	3.5	14.4	10.9	2.3	1.2	12.3	7.6
M24	26.9	4.7	87.7	11.3	5.8	0.6	95.1	3.1	27.0	12.0	1.6	1.4	12.1	8.3
P	< 0.0011		< 0.0011		< 0.0011		< 0.0011		0.083		0.869		0.100

¹Statistically significant. SD: Standard deviation; BMI: Body mass index; HbA1c: Hemoglobin A1c; FBS: Fasting blood sugar; MMP: Matrix metalloproteinases; M0: The baseline prior to surgery; M3: 3 mo postoperatively; M12: 12 mo postoperatively; M24: 24 mo postoperatively.