Effect of liraglutide on endoplasmic reticulum stress in the renal tissue of type 2 diabetic rats

Table 1 Comparison of changes in body weights and fasting blood glucose levels among the four groups of rats

Group	n	Weight (g) (mean ± SD)	FBG (mmol/L) (mean ± SD)
Control group	6	477.17 ± 23.82	4.58 ± 0.69
Model group	6	396.51 ± 9.15	22.57 ± 1.42
Low-dose liraglutide group	6	440.02 ± 34.22	19.43 ± 1.07
High-dose liraglutide group	6	434.67 ± 39.42	17.32 ± 1.02
P value		< 0.05	< 0.05

FBG: Fasting blood glucose; SD: Standard deviation.

Table 2 Changes in biochemical indices in rats from each group

Biochemical index	Control group	Model group	Low-dose liraglutide group	High-dose liraglutide group
Scr (µmol/L)	51.05 ± 2.14	74.14 ± 4.361	64.40 ± 0.682	58.39 ± 2.803
BUN (mmol/L)	4.82 ± 0.61	9.72 ± 0.891	8.21 ± 0.922	6.26 ± 0.463
24-h urine protein (g/24 h)	0.35 ± 0.18	3.51 ± 0.811	2.34 ± 0.392	1.48 ± 0.413

¹Indicates significant differences in comparison with the control group.

²Indicates significant differences in comparison with the model group.

³Indicates significant differences in comparison with the low-dose liraglutide group. Scr: Serum creatinine; BUN: Blood urea nitrogen.