Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

Figure 2 Duodenal jejunal bypass surgery inhibits hypothalamic oxidative stress in rats with type 2 diabetes mellitus by activating the Nrf2/HO-1 signaling pathway. A: Analysis of SOD content in the hypothalamus of rats; B: Analysis of MDA content in the hypothalamus of rats; C: Nrf2 and HO-1 expression in the hypothalamus detected by immunofluorescence (scale bar, 130 µm); D: The percentage of cells expressing Nrf2; E: The percentage of cells expressing HO-1; F: Expression levels of Nrf2 and HO-1 in hypothalamus detected by Western blotting; G: The quantitative densitometric analysis of Nrf2 and HO-1. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. T2DM: Type 2 diabetes mellitus; DJB: Duodenal jejunal bypass.