Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus

doi:10.4239/wjd.v9.i9.149

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Sep 15, 2018; 9(9): 149-156
Published online Sep 15, 2018. doi: 10.4239/wjd.v9.i9.149

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Figure 1 The experimental protocol. Group 1: Control rats with T2DM without therapy; Group 2: IpMI (rats treated with insulin prior to MI); Group 3: IaMI (rats treated with insulin after MI); Group 4: GLP1pMI (rats treated with GLP-1a prior to MI); Group 5: GLP1aMI (rats treated with GLP-1a after MI); Group 6: GLP1pMI + IaMI (rats treated with GLP-1a prior to MI and with insulin after MI).

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Figure 2 Comparison of the necrotic zone and zone at risk between different drugs. Control: Rats with T2DM without therapy; IpMI: Rats treated with insulin prior to MI; IaMI: Rats treated with insulin after MI.

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Figure 3 Comparison of the necrotic zone and zone at risk between different drugs. GLP1pMI: Rats treated with GLP-1a prior to MI; GLP1aMI: Rats treated with GLP-1a after MI; GLP1pMI + IaMI: Rats treated with GLP-1a prior to MI and with insulin after MI.

Citation: Zykov VA, Tuchina TP, Lebedev DA, Krylova IB, Babenko AY, Kuleshova EV, Grineva EN, Bayramov AA, Galagudza MM. Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus. World J Diabetes 2018; 9(9): 149-156
URL: https://www.wjgnet.com/1948-9358/full/v9/i9/149.htm
DOI: https://dx.doi.org/10.4239/wjd.v9.i9.149