Clinical therapeutic strategies for early stage of diabetic kidney disease

Figure 1 Therapeutic strategy for diabetic kidney disease. Multifactorial therapy, consisting of glycemic, blood pressure, and lipid control, is recommended to prevent the progression of diabetic kidney disease (DKD). The remission and regression of albuminuria by multifactorial therapy may be closely associated with reduced risk of progression of both DKD and cardiovascular disease. In addition to these therapies, vitamin D receptor activation, uric acid-lowering drugs, and incretin-related drugs should be considered in the prospective treatment of DKD.

Figure 2 Beneficial effects of renin-angiotensin system inhibitors. Numerous landmark studies have shown the effectiveness of renin-angiotensin system inhibitors on diabetic kidney disease.