Rheb1 as a novel β-cell regulator connecting mTORC1, AMPK, and NOTCH1 pathways for efficient diabetes therapy

Figure 1 Mechanistic illustration of Ras homolog enriched in brain 1 as a central regulator of β-cell mass and its integrating function on mammalian target of rapamycin complex 1, AMP-activated protein kinase, neurogenic locus notch homolog protein 1, and hepatocyte nuclear factor 4 alpha pathways. Ras homolog enriched in brain 1 plays a critical role in both β-cell proliferation and identity, and its dysregulation contributes to diabetes pathogenesis. Rheb1: Ras homolog enriched in brain 1; Notch1: Neurogenic locus notch homolog protein 1; MTORC1: Mammalian target of rapamycin complex 1; HNF4: Hepatocyte nuclear factor 4 alpha; MODY1: Maturity-onset diabetes of the young 1.