L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes

Figure 1 Effects of low-dose and high-dose L-arginine in patients with type 2 diabetes. Low doses (≤ 0.5 g/kg) of L-arginine can improve blood lipid levels, whereas high doses (≥ 1 g/kg) of L-arginine can exacerbate oxidative stress and cause myocardial damage. NO: Nitric oxide; ROS: Reactive oxygen species.

Figure 2 Excess L-arginine daily administration causes cardiac injury in diabetes mellitus patients. 0.5 g/kg L-arginine is beneficial for the treatment of diabetes and is the threshold of cardiac safety. NO: Nitric oxide.