Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy

doi:10.4239/wjd.v16.i4.101994

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Apr 15, 2025 (publication date) through Feb 28, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Apr 15, 2025; 16(4): 101994
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.101994

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Figure 1 A novel mechanism targeting β-arrestin-2 for the management of diabetic nephropathy. β-arrestin-2 may trigger endoplasmic reticulum stress via activating transcription factor 6 signaling pathway, thereby promoting glomerular endothelial cell apoptosis and exacerbating diabetic nephropathy progression. ER: Endoplasmic reticulum; ATF6: Activating transcription factor 6. The schematic model is plotted with BioRender (https://www.biorender.com).

Citation: Liu N, Yan WT, Xiong K. Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy. World J Diabetes 2025; 16(4): 101994
URL: https://www.wjgnet.com/1948-9358/full/v16/i4/101994.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i4.101994