Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients

Figure 1 Study participant selection from the Action to Control Cardiovascular Risk in Diabetes/Action to Control Cardiovascular Risk in Diabetes Follow-On study. TyG: Triglyceride glucose; WHtR: Waist height ratio; WC: Waist circumference; ACCORD: The Action to Control Cardiovascular Risk in Diabetes; ACCORDION: The Action to Control Cardiovascular Risk in Diabetes Follow-On.

Figure 2 Kaplan-Meier curves for major adverse cardiovascular events and total mortality with triglyceride glucose-waist height ratio and triglyceride glucose-waist circumference. MACEs: Major adverse cardiovascular events; TyG: Triglyceride glucose; WHtR: Waist height ratio; WC: Waist circumference.

Figure 3 Restricted cubic spline analysis of triglyceride glucose-waist height ratio and triglyceride glucose-waist circumference to estimate the risk of major adverse cardiovascular events and total mortality. The hazard ratios shown are adjusted for Model 3, including sex, race, age, education, history of cardiovascular disease, previous hypertension and previous hyperlipidemia systolic blood pressure, diastolic blood pressure, duration of diabetes, proteinuria, heart failure, depression, smoking, glycated hemoglobin, total cholesterol, low-density lipoprotein cholesterol, estimated glomerular filtration rate, calcium channel blockers, beta-blockers, biguanides, thiazolidinediones, insulins, aspirin, statins and cholesterol absorption inhibitors. TyG: Triglyceride glucose; WHtR: Waist height ratio; WC: Waist circumference; MACEs: Major adverse cardiovascular events.

Figure 4 Receiver operator operating characteristic curve analysis for triglyceride glucose-waist height ratio and triglyceride glucose-waist circumference predicted major adverse cardiovascular events and total mortality. MACEs: Major adverse cardiovascular events; AUC: Area under the curve; TyG: Triglyceride glucose; WHtR: Waist height ratio; WC: Waist circumference.