MicroRNA-630: A promising avenue for alleviating inflammation in diabetic kidney disease

Figure 1 Toll-like receptor activation by binding of damage-associated molecular patterns or pathogen-associated molecular patterns results in nuclear translocation of nuclear factor-kappa B transcription factors. According to the results of Wu et al[23], microRNA-630 reduces the renal Toll-like receptor 4 levels diabetic kidney disease in rats, attenuates the expression of pro-inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and improves albuminuria and glycemia. DAMPs: Damage-associated molecular patterns; TLR: Toll-like receptor; NF-κB: Nuclear factor-kappa B.