Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy

doi:10.4239/wjd.v15.i11.2189

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Nov 15, 2024 (publication date) through Oct 17, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Nov 15, 2024; 15(11): 2189-2202
Published online Nov 15, 2024. doi: 10.4239/wjd.v15.i11.2189

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Figure 1 Mechanisms of different forms of autophagy-dependent ferroptosis. GPX4: Glutathione peroxidase 4; ARNTL1: Aryl hydrocarbon receptor nuclear translocator-like protein 1; LAMP2A: Lysosome-associated membrane protein type 2A; PINK1-PRKN: PTEN-induced kinase 1 parkin RBR E3 ubiquitin protein ligase; SLC25A35: Solute carrier family 25 member 37; SLC25A38: Solute carrier family 25 member 28; NCOA4: Nuclear receptor coactivator 4; FTH1: Ferritin heavy chain 1.

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Figure 2 Impact of autophagy-dependent ferroptosis on the retinal neurovascular unit. NVU: Neurovascular unit; ROS: Reactive oxygen species.

Citation: Sun WJ, An XD, Zhang YH, Tang SS, Sun YT, Kang XM, Jiang LL, Zhao XF, Gao Q, Ji HY, Lian FM. Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy. World J Diabetes 2024; 15(11): 2189-2202
URL: https://www.wjgnet.com/1948-9358/full/v15/i11/2189.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i11.2189