Novel insights regarding the role of noncoding RNAs in diabetes

doi:10.4239/wjd.v14.i7.958

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2023; 14(7): 958-976
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.958

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Figure 1 Mechanism of action of miRNAs. AGO: Argonaute family of protein; miRNA: microRNA; miRISC: miRNA-induced silencing complex; pre-RNA: Precursor RNA; pri-miRNA: Primary miRNA; pre-miRNA: Precursor miRNA; 3′UTR: 3′ untranslated region; 5′ UTR: 5′ untranslated region.

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Figure 2 The role of specific miRNAs in DM. miRNAs: micro RNAs; DM: Diabetes mellitus.

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Figure 3 miRNAs mediating glucose metabolism and insulin secretion in pancreatic β-cells. Foxa2: Forkhead box A2; KATP channel: ATP-sensitive potassium channel; MAP4K4: Mitogen-activated protein kinase kinase kinase kinase 4; MCT1: Monocarboxylate transporter 1; Mtpn: Myotrophin; PDK1: Phosphoinositide-dependent protein kinase 1; Rab27a: Member RAS oncogene family; Sirt1: Sirtuin (silent mating type information regulation 2 homologs) 1; SNARE: Soluble N-ethylmaleimide-sensitive factor activating protein receptor; Vamp2: Vesicle-associated membrane protein 2; UCP2: Uncoupling protein 2.

Citation: Macvanin MT, Gluvic Z, Bajic V, Isenovic ER. Novel insights regarding the role of noncoding RNAs in diabetes. World J Diabetes 2023; 14(7): 958-976
URL: https://www.wjgnet.com/1948-9358/full/v14/i7/958.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i7.958