Adiponectin as a therapeutic target for diabetic foot ulcer

Figure 1  The common pathways in diabetes mellitus leading to infected foot ulcer.

Figure 2  The role of low adiponectin in contributing to delayed wound healing.

Figure 3 The Potential mechanisms involved in adiponectin-mediated wound healing in diabetic foot ulcers. AdipoRon: Adiponectin receptor agonist; AdipoR1/AdipoR2: adiponectin receptors 1 and 2; MAPK: Mitogen-activated protein kinases; IRS2: Insulin receptor substrate 2; AMAK: Adenosine monophosphate-activated kinase; mTOR: Mammalian target of rapamycin; ECM: Extracellular matrix.