Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing

doi:10.4239/wjd.v13.i12.1066

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Dec 15, 2022 (publication date) through Nov 21, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2022; 13(12): 1066-1095
Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1066

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Figure 1 Molecular mechanism of mesenchymal stem cell-derived exosomes in diabetic cutaneous wound healing. A: signaling pathways most frequently studied in diabetic wound models and may potentially confirmed in diabetic chronic wounds; B: microenvironmental changes in inflammatory stage of wound healing after using mesenchymal stem cell-derived exosomes; C: microenvironmental changes in proliferative stage of wound healing after using mesenchymal stem cell-derived exosomes. PTEN: Phosphatase and tensin homolog; PI3K: Phophatidylinositol3-kinase; Akt/PKB: Protein kinase B; RAS: Rat sarcoma; Raf: Rapidly accelerated fibrosarcoma; MAPK: Mitogen-activated protein; ERK: Extracellular signal regulated kinase; NF-κB: Nuclear factor kappa-B; TGF-β: Transforming growth factor-β; Smad2/3/4: Drosophila mothers against decapentaplegic.

Citation: Wu J, Chen LH, Sun SY, Li Y, Ran XW. Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing. World J Diabetes 2022; 13(12): 1066-1095
URL: https://www.wjgnet.com/1948-9358/full/v13/i12/1066.htm
DOI: https://dx.doi.org/10.4239/wjd.v13.i12.1066