Dr. Changjie Wu, PhD, Associate Professor in the Department of Gastroenterology at Nanfang Hospital, Southern Medical University. Working on "Exploiting Synthetic Lethality for Cancer Precision Medicine". Synthetic lethality refers to a genetic interaction in which the loss of a single gene does not affect cell viability, but the simultaneous loss of two genes results in cell death. This concept has become a pivotal approach in cancer research, as many cancers harbor loss-of-function mutations in tumor suppressor genes. By targeting synthetic lethality, researchers can use these mutations as markers to enhance the selectivity of anticancer therapies. Pharmacological or genetic disruption of a synthetic lethal partner of a tumor suppressor gene leads to the selective killing of cancer cells with the tumor suppressor mutation. Due to its high specificity for cancer cells, synthetic lethality is a key strategy in cancer precision medicine. As the first or corresponding author, published four papers in Nature Communications, Cell Death & Disease, and Neoplasia, with over 200 citations. The H-index is 12. Served as a reviewer for the Journal of Translational Medicine and the Journal of Southern Medical University. Mainly focuses on identifying synthetic lethality partners through chemical and genetic screenings, as well as translational research. He has Possesses strong leadership and teamwork skills. He's hobbies are climbing, badminton.