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©The Author(s) 2017.
World J Gastrointest Endosc. Aug 16, 2017; 9(8): 389-395
Published online Aug 16, 2017. doi: 10.4253/wjge.v9.i8.389
Published online Aug 16, 2017. doi: 10.4253/wjge.v9.i8.389
Table 1 Baseline characteristics n (%)
| Biopsy/surgical specimen diagnosis | P value | |||
| Total (n = 144) | Neoplastic lesions (n = 41) | Non-neoplastic lesions (n = 103) | ||
| Sex (female) | 74 (51.4) | 19 (46.3) | 55 (53.4) | 0.445 |
| Age, yr, mean ± SD | 51.33 ± 16.5 | 56.73 ± 17.1 | 49.19 ± 15.8 | 0.014 |
| Initial endoscopy indication | < 0.001 | |||
| Suspected tumor | 70 (48.6) | 32 (78.0) | 38 (36.9) | |
| Other | 74 (51.4) | 9 (22.0) | 65 (63.1) | |
| Location | 0.187 | |||
| Vater ampulla | 2 (1.4) | 1 (2.4) | 1 (1.0) | |
| Colon | 14 (9.7) | 6 (14.6) | 8 (7.8) | |
| Duodenum | 4 (2.8) | 1 (2.4) | 3 (2.9) | |
| Esophagus | 24 (16.7) | 8 (19.5) | 16 (15.5) | |
| Stomach | 59 (41.0) | 10 (24.4) | 49 (47.6) | |
| Ileum | 1 (0.7) | 0 (0.0) | 1 (1.0) | |
| Pancreas | 8 (5.6) | 1 (2.4) | 7 (6.8) | |
| Rectum | 3 (2.1) | 1 (2.4) | 2 (1.9) | |
| Bile duct | 29 (20.1) | 13 (31.7) | 16 (15.5) | |
Table 2 Confocal laser endomicroscopy overall diagnostic accuracy with either confocal laser endomicroscopy target biopsy or surgical specimens as the Gold Standard n (%)
| Biopsy/surgical specimen diagnosis | P value | |||
| Total (n = 144) | Neoplastic lesions (n = 41) | Non-neoplastic lesions (n = 103) | ||
| CLE diagnosis | < 0.001 | |||
| Neoplastic lesion | 48 (33.3) | 35 (85.4) | 13 (12.6) | |
| Non-Neoplastic lesion | 96 (66.7) | 6 (14.6) | 90 (87.4) | |
| CLE overall diagnostic accuracy | ||||
| Sensitivity, n/T (%; 95%CI) | 35/41 | (85.37; 70.83-94.43) | ||
| Specificity, n/T (%; 95%CI) | 90/103 | (87.38; 79.38-93.11) | ||
| PPV, n/T (%; 95%CI) | 35/48 | (72.92; 61.46-81.97) | ||
| NPV, n/T (%; 95%CI) | 90/96 | (93.75; 87.71-96.93) | ||
| Observed agreement, n/T (%) | 125/144 | -86.81 | ||
| Cohen’s Kappa, % (95%CI) | 69.2 | (56.50-81.90) | ||
Table 3 Patients with changes in management following biopsy/surgical specimen diagnosis, listed according to organ n (%)
| Biopsy/surgical specimen diagnosis | P value | |||
| Total (n = 78) | Neoplastic lesions (n = 30) | Non-neoplastic lesions (n = 48) | ||
| Location | 0.707 | |||
| Vater ampulla | 1 (1.3) | 1 (3.3) | 0 | |
| Colon | 9 (11.5) | 4 (13.3) | 5 (10.4) | |
| Duodenum | 4 (5.1) | 1 (3.3) | 3 (6.3) | |
| Esophagus | 10 (12.8) | 5 (16.7) | 5 (10.4) | |
| Stomach | 17 (21.8) | 5 (16.7) | 12 (25) | |
| Ileum | 1 (1.3) | 0 | 1 (2.1) | |
| Pancreas | 6 (7.7) | 1 (3.3) | 5 (10.4) | |
| Rectum | 3 (3.8) | 1 (3.3) | 2 (4.2) | |
| Bile duct | 27 (34.6) | 12 (40) | 15 (31.3) | |
- Citation: Robles-Medranda C, Vargas M, Ospina J, Puga-Tejada M, Valero M, Soria M, Bravo G, Robles-Jara C, Lukashok HP. Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis. World J Gastrointest Endosc 2017; 9(8): 389-395
- URL: https://www.wjgnet.com/1948-5190/full/v9/i8/389.htm
- DOI: https://dx.doi.org/10.4253/wjge.v9.i8.389