Does deep sedation with propofol affect adenoma detection rates in average risk screening colonoscopy exams?

Table 1 Patient characteristics by type of sedation

	Moderate sedation, n (%)	Propofol sedation, n (%)	P value
Total	1730 (66.4)	874 (33.6)
Gender			0.16
Female	1133 (67.4)	548 (32.6)
Male	597 (64.7)	326 (35.3)
Race			< 0.0001
Non-Hispanic White	1190 (66.2)	607 (33.8)
African American	166 (55.7)	132 (44.3)
Hispanic	186 (65.5)	98 (34.5)
Asian	172 (83.9)	33 (16.1)
Unknown	16 (80.0)	4 (20.0)
BMI			< 0.0001
< 25	617 (81.8)	137 (18.2)
25-30	645 (76.0)	204 (24.0)
> 30	451 (45.8)	533 (54.2)
Missing	17 (100)	0 (0)
Mean age (SD)	55.4 (5.3)	56.7 (5.9)	< 0.0001
Adenoma			0.01
No	1017 (58.8)	469 (53.7)
Yes	713 (41.2)	405 (46.3)
Mean insertion time, min (SD)	8.2 (6.5)	6.9 (4.7)	< 0.0001
Mean scope withdrawal time, min (SD)	12.8 (6.3)	12.6 (6.6)	0.75
Advanced adenoma detection rate (SD)	134 (7.8)	95 (10.4)	0.065
Sessile serrated adenoma detection rate (SD)	106 (6.1)	54 (5.9)	0.52

Table 2 Multivariable analysis: Association of type of sedation (propofol vs moderate) with adenoma detection rate and scope insertion time

	Variable	Propofol, n (%)	Crude odds ratio (95%CI)	P value	Adjusted odds ratio1 (95%CI)	P value
Adenoma detection
Gender	Female	548 (32.6)	1.27 (1.03-1.56)	0.03	1.07 (0.84-1.35)	0.60
	Male	326 (35.3)	1.14 (0.87-1.49)	0.34	1.16 (0.87-1.55)	0.32
Scope insertion time, mean (SD)
Gender	Female	7.3 (5.0)	0.96 (0.94-0.97)	< 0.001	0.97 (0.95-0.99)	0.02
	Male	6.3 (4.2)	0.96 (0.60-0.99)	0.02	0.97 (0.93-1.00)	0.05

¹Adjusted for patient age and body mass index.