Oral esomeprazole vs injectable omeprazole for the prevention of hemorrhage after endoscopic submucosal dissection

Table 1 Background characteristics of the patients in relation to the bleeding status

	Hemorrhage after ESD		P value
	Negative	Positive
Number	210	33
Age (yr)	73.9 ± 8.0	71.7 ± 9.4	0.14
Gender (M/F)	151/59	8/25	0.65
Antiplatelet/anticoagulant drugs (-/+)	161/49	8/25	0.91
Hypertension (-/+)	123/87	20/13	0.83
Diabetes mellitus (-/+)	186/24	4/27	0.52
H. pylori infection (-/+)	90/120	13/20	0.89
Location (U/M/L)	28/96/86	2/15/16	0.45
Depth (m/sm)	190/20	5/28	0.35
Ulcer (-/+)	205/5	33/0	0.37
Diameter of the lesion (mm)	40.7 ± 15.3	40.4 ± 13.9	0.89
Duration of the operation (min)	106.9 ± 64.1	123.8 ± 98.5	0.2
Macroscopic type of the lesion (elevated or flat/combined/depressed)	130/29/51	5/10/2018	0.49
Pathological findings (Adenoma/Differentiated ca/Undifferentiated ca)	76/126/8	12/21/0	0.32
Lymphatic/venous invasion (-/+)	206/4	Jan-32	0.67
Anastomosis (-/+)	200/10	33/0	0.2
Operator type (expert/beginner)	129/81	14/19	0.0392
Bleeding during ESD (good/poor control)	164/46	9/24	0.49

P value calculated by the χ² test (Fisher’s exact test or Pearson’s test). ESD: Endoscopic submucosal dissection; H. pylori: Helicobacter pylori.

Table 2 Background characteristics of the patients according to the treatment group before the propensity score matching

	EPZ group	OPZ group	P value
Number	71	172
Age (yr)	75.3 ± 7.1	72.9 ± 8.5	0.0361
Gender (M/F)	52/19	124/48	0.86
Antiplatelet/anticoagulant drugs (-/+)	50/21	136/36	0.15
Hypertension (-/+)	40/31	103/69	0.61
Diabetes Mellitus (-/+)	Sep-62	151/21	0.92
H. pylori infection (-/+)	29/42	55/117	0.19
Location (U/M/L)	10/34/27	20/77/75	0.7
Depth (m/sm)	57/14	161/11	0.0019
Ulcer (-/+)	71/0	167/5	0.15
Diameter of the lesion (mm)	42.2 ± 17.2	40.14 ± 14.1	0.31
Duration of the operation (min)	115.9 ± 87.3	106.4 ± 61.1	0.34
Macroscopic type of the lesion (elevated or flat/combined/depressed)	46/16/9	102/18/52	0.003
Pathological findings (Adenoma/Differentiated ca/Undifferentiated ca)	26/42/3	62/105/5	0.86
Lymphatic/venous invasion (-/+)	Jan-70	168/4	0.65
Anastomosis (-/+)	Mar-68	163/9	0.74
Operator type (expert/beginner)	31/40	112/60	0.002
Bleeding during ESD (good/poor control)	55/16	134/38	0.94
Hemorrhage after ESD (-/+)	149/23	Oct-61	0.88
Clinically significant bleeding (-/+)	165/7	Mar-68	0.96

P value calculated by the χ² test (Fisher’s exact test or Pearson’s test). EPZ: Esomeprazole; OPZ: Omeprazole; ESD: Endoscopic submucosal dissection.

Table 3 Background characteristics of the patients according to the treatment group after the propensity score matching

	EPZ group	OPZ group	P value
Number	65	65
Age (yr)	75.2 ± 7.3	75.0 ± 7.5	0.9
Gender (M/F)	46/19	44/21	0.85
Antiplatelet/anticoagulant drugs (-/+)	46/19	44/21	0.85
Hypertension (-/+)	37/28	33/32	0.6
Diabetes Mellitus (-/+)	Aug-57	Dec-53	0.47
H. pylori infection (-/+)	26/39	23/42	0.72
Location (U/M/L)	5/33/27	10/24/31	0.19
Depth (m/sm)	Sep-56	Jun-59	0.58
Ulcer (-/+)	65/0	65/0	0
Diameter of the lesion (mm)	41.9 ± 18.5	39.6 ± 12.1	0.4
Duration of the operation (min)	110.6 ± 85.7	102.0 ± 54.9	0.5
Macroscopic type of the lesion (elevated or flat/combined/depressed)	42/14/9	10/8/1947	0.6
Pathological findings (Adenoma/Differentiated ca/Undifferentiated ca)	26/37/2	29/35/1	0.76
Lymphatic/venous invasion (-/+)	Jan-64	Feb-63	≥ 0.99
Anastomosis (-/+)	Mar-62	Mar-62	≥ 0.99
Operator type (expert/beginner)	29/36	27/38	0.86
Bleeding during ESD (good/poor control)	51/14	49/16	0.84
Hemorrhage after ESD (-/+)	Oct-55	Nov-54	≥ 0.99
Clinically significant bleeding (-/+)	Apr-61	Mar-62	≥ 0.99

P value calculated by the χ² test (Fisher’s exact test or Pearson’s test). EPZ: Esomeprazole; OPZ: Omeprazole; ESD: Endoscopic submucosal dissection.