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©The Author(s) 2016.
World J Gastrointest Endosc. Apr 10, 2016; 8(7): 330-337
Published online Apr 10, 2016. doi: 10.4253/wjge.v8.i7.330
Published online Apr 10, 2016. doi: 10.4253/wjge.v8.i7.330
Table 1 Clinicopathologic feature of the 415 lesions treated with endoscopic submucosal dissection
No. of lesions | |
n = 415 | |
Age, yr (mean ± SD) | 64.2 ± 9.8 |
Sex, n (%) | |
Male | 291 (70.1) |
Female | 124 (29.9) |
Gross type of tumor, n (%) | |
Protruded (I) | 29 (7.0) |
Superficial elevated (IIa) | 146 (35.2) |
Flat (IIb) | 76 (18.3) |
Superficial depressed (IIc) | 134 (32.3) |
Excavated (III) | 2 (0.5) |
Mixed | 28 (6.7) |
En bloc resection, n (%) | 415 (100) |
Piecemeal resection, n (%) | 0 (0) |
Tumor location, n (%) | |
Upper | 15 (3.6) |
Mid | 129 (30.9) |
Lower | 271 (65.0) |
Tumor size, n (%) | |
≤ 20 mm | 116 (28.0) |
21-30 mm | 77 (18.8) |
31-40 mm | 122 (29.4) |
> 40 mm | 100 (24.1) |
Histology, n (%) | |
Well differentiated | 195 (47.0) |
Moderate differentiated | 180 (43.4) |
Poorly differentiated | 30 (7.2) |
Signet ring cell | 10 (2.4) |
Follow-up period, mo (mean ± SD) | 19.7 ± 17.5 |
Table 2 Risk factor associated with neoplasia recurrence
Recurrence | No recurrence | Univariate | Multivariate | |
n = 36 | n = 379 | P value | P value | |
Age, yr (mean ± SD) | 66.7 ± 9.0 | 64.0 ± 9.9 | 0.11 | |
Male/female | 25/11 | 266/113 | 0.93 | |
Tumor margin, n (%) | 0.02 | 0.03 | ||
Well-defined | 24 (66.7) | 313 (82.6) | ||
Ill-defined | 12 (33.3) | 66 (17.4) | ||
Tumor size, n (%) | 0.62 | |||
≤ 20 mm | 9 (25.0) | 107 (28.2) | ||
21-30 mm | 6 (16.7) | 71 (18.7) | ||
31-40 mm | 14 (38.9) | 108 (28.5) | ||
> 40 mm | 7 (19.4) | 93 (24.5) | ||
Tumor location, n (%) | 0.05 | |||
Upper | 3 (8.3) | 12 (3.2) | ||
Mid | 14 (38.9) | 115 (30.3) | ||
Lower | 19 (52.8) | 252 (66.5) | ||
Histology, n (%) | 0.7 | |||
Well differentiated | 17 (47.2) | 178 (47.0) | ||
Moderate differentiated | 13 (36.1) | 167 (44.1) | ||
Poorly differentiated | 6 (16.7) | 24 (6.3) | ||
Signet ring cell | 0 (0.0) | 10 (2.6) | ||
Procedure time, min (mean ± SD) | 63.5 ± 56.9 | 48.8 ± 34.3 | 0.02 | 0.06 |
Safety margin, mm (mean ± SD) | 3.1 ± 2.1 | 4.2 ± 2.9 | 0.03 | 0.05 |
Table 3 Factors associated with sufficient safety margin after endoscopic submucosal dissection (Univariate)
Safety margin ≤1 mm | Safety margin > 1 mm | P value | |
n = 63 | n = 352 | ||
Age, yr (mean ± SD) | 65.9 ± 11.1 | 63.9 ± 9.5 | 0.14 |
Male/female | 38/25 | 253/99 | 0.12 |
Tumor margin, n (%) | 0.52 | ||
Well-defined | 53 (84.1) | 284 (80.7) | |
Ill-defined | 10 (15.9) | 68 (19.3) | |
Tumor size, n (%) | 0.55 | ||
≤ 20 mm | 21 (33.3) | 95 (27.0) | |
21-30 mm | 12 (19.0) | 65 (18.5) | |
31-40 mm | 14 (22.2) | 108 (30.7) | |
> 40 mm | 16 (25.4) | 84 (23.9) | |
Tumor location, n (%) | < 0.0001 | ||
Upper | 7 (11.1) | 8 (2.3) | |
Mid | 31 (49.2) | 98 (27.8) | |
Lower | 25 (39.7) | 246 (69.9) | |
Histology, n (%) | 0.85 | ||
Well differentiated | 32 (50.8) | 163 (46.3) | |
Moderate differentiated | 24 (38.1) | 156 (44.3) | |
Poorly differentiated | 3 (4.8) | 27 (7.7) | |
Signet ring cell | 4 (6.3) | 6 (1.7) | |
Procedure time, min (mean ± SD) | 58.9 ± 43.8 | 48.5 ± 35.4 | 0.04 |
Table 4 Factors associated with sufficient safety margin after endoscopic submucosal dissection (Multivariate)
Multivariate analysis | ||
Odds ratio (95%CI) | P value | |
Location | ||
Upper | 2.90 (1.11-7.58) | 0.03 |
Mid | 1.10 (0.48-2.55) | 0.82 |
Lower | 1 (ref) | |
Ill-defined margin | 2.32 (1.00-4.96) | 0.03 |
Table 5 Neoplasia recurrence and cancer recurrence by safety margin 1 mm n (%)
Safety margin ≤1 mm | Safety margin > 1 mm | P value | |
n = 63 | n = 352 | ||
Neoplasia recurrence | 9 (14.3) | 27 (7.7) | 0.09 |
Cancer recurrence | 4 (6.3) | 2 (0.6) | 0.006 |
- Citation: Lee JY, Cho KB, Kim ES, Park KS, Lee YJ, Lee YS, Jang BK, Chung WJ, Hwang JS. Risk factors for local recurrence after en bloc endoscopic submucosal dissection for early gastric cancer. World J Gastrointest Endosc 2016; 8(7): 330-337
- URL: https://www.wjgnet.com/1948-5190/full/v8/i7/330.htm
- DOI: https://dx.doi.org/10.4253/wjge.v8.i7.330