Laparoscopic splenectomy for primary immune thrombocytopenia: Current status and challenges

Table 1 Case series reporting 50 or more patients undergoing splenectomy for immune thrombocytopenia that contain platelet count response

Publication date	Accrual years	Ref.	Country	No. patients	Operation method	CR rate	R rate	NR rate	Relapse
20061	1993-2003	Balagué et al[34]	Spain	103	LS	NA	NA	4.9%	6.1%
20072	1988-2006	Sampath et al[29]	Canada	105	LS, OS	NA	NA	NA	21.6%
20071	1994-2004	Kang et al[35]	South Korea	59	LS	47.5%	40.7%	11.9%	15.2%
20113	2005-2010	Chen et al[36]	China	81	LS	88.9%	8.6%	2.5%	NA
20114	1999-2006	Zheng et al[37]	China	127	LS	79.5%	9.5%	11%	9.7%
20133	1982-2011	Gonzalez-Porras et al[38]	Spain	218	LS, OS	80.7%	8.3%	11.0%	36.1%
20143	1995-2012	Montalvo et al[39]	Mexico	150	LS	88.7%	2.7%	8.6%	NA
20143	2001-2009	Rijcken et al[40]	Germany	72	LS	77.8%	9.7%	12.5%	30.2%
20143	2010-2012	Cai et al[41]	China	88	LS	77.3%	19.3%	3.4%	NA
20153	1992-2013	Navez et al[42]	Belgium	82	LS	72.0%	24.4%	3.6%	NA

¹Remission was defined as CR when platelet count increased to > 150 × 10⁹/L, and as R when it was 50-150 × 10⁹/L;

²The criterion of ITP remission was not mentioned in the study;

³Remission was defined as CR when platelet count increased to > 100 × 10⁹/L, and as R when it was 30-100 × 10⁹/L;

⁴Remission was defined as CR when platelet count increased to > 100 × 10⁹/L, and as R when it was 50-100 × 10⁹/L. OS: Open splenectomy; LS: Laparoscopic splenectomy; CR: Complete response; R: Response; NR: No response; ITP: Immune thrombocytopenia.