Azzam N, Aljebreen AM, Alharbi O, Almadi MA. Prevalence and clinical features of colonic diverticulosis in a Middle Eastern population. World J Gastrointest Endosc 2013; 5(8): 391-397 [PMID: 23951394 DOI: 10.4253/wjge.v5.i8.391]
Corresponding Author of This Article
Dr. Majid A Almadi, Division of Gastroenterology, Department of Medicine, King Khalid University Hospital, King Saud University, PO Box 2925(59), Riyadh 11461, Saudi Arabia. maalmadi@ksu.edu.sa
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
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World J Gastrointest Endosc. Aug 16, 2013; 5(8): 391-397 Published online Aug 16, 2013. doi: 10.4253/wjge.v5.i8.391
Table 1 Comorbidities of patients and indications for a colonoscopy for the complete cohort of patients
Variable
Percentage
95%CI
Comorbidities
Hypertension
63.88%
52.52-75.25
Diabetes
44.44%
32.68-56.20
Dyslipidemia
22.22%
12.38-32.06
Aspirin
10.07%
8.35-11.82
Chronic kidney disease
5.55%
0.10-11.00
Coronary artery disease
4.16%
0.10-9.00
Indication for colonoscopy
Bleeding per rectum
22.94%
21.50-24.38
Abdominal pain
19.30%
17.94-20.64
Surveillance
16.29%
15.03-17.55
Constipation
9.57%
8.57-10.58
Diarrhea
8.75%
7.79-9.72
Screening
7.57%
6.67-8.48
Weight loss
5.50%
4.72-6.28
Anemia
5.02%
4.27-5.76
Melena
3.13%
2.54-3.73
Anal pain
1.91%
1.45-2.38
Altered bowel habits
1.76%
1.31-2.21
Perianal fistula
1.19%
0.82-1.55
Positive for occult blood
0.52%
0.27-0.76
Table 2 Comorbidities of patients and indications for a colonoscopy stratified by the presence and absence of diverticulosis as well as the univariable analysis between the presence of diverticulosis and the corresponding variables
Variable
Diverticulosis
No diverticulosis
P-value
Univariable analysis
OR
95%CI
Comorbidities
Hypertension
63.88%
25.92%
< 0.01
5.05
3.06-8.34
Diabetes
44.44%
24.32%
< 0.01
2.49
1.53-4.05
Dyslipidemia
22.22%
10.77%
0.03
2.37
1.31-4.27
Aspirin
21.33%
9.23%
0.01
2.67
1.48-4.81
Chronic kidney disease
5.56%
3.12%
0.38
2.91
0.82-10.29
Coronary artery disease
4.16%
1.43%
0.27
1.82
0.62-5.30
Indication for colonoscopy
Bleeding per rectum
33.60%
22.08%
< 0.01
1.79
1.35-2.35
Abdominal pain
19.30%
15.20%
0.06
0.73
0.51-1.05
Constipation
12.80%
9.31%
0.11
1.43
0.96-2.11
Surveillance
10.40%
16.72%
< 0.01
0.58
0.38-0.87
Screening
6.40%
7.67%
0.43
0.82
0.49-1.39
Anemia
6.00%
4.94%
0.5
1.23
0.71-2.12
Melena
3.13%
4.40%
0.31
1.47
0.78-2.79
Diarrhea
2.40%
9.28%
< 0.01
0.24
0.11-0.55
Altered bowel habits
2.00%
1.74%
0.78
1.15
0.46-2.90
Weight loss
2.00%
5.79%
< 0.01
0.33
0.14-0.82
Anal pain
1.20%
1.97%
0.29
0.6
0.19-1.94
Positive for occult blood
1.20%
0.46%
0.29
2.62
0.75-9.19
Perianal fistula
0.40%
1.25%
0.06
0.32
0.04-2.32
Table 3 Variables associated with the presence of diverticulosis on multivariable analysis
Variable
Multivariable analysis
OR
95%CI
Age
1.05
1.03-1.07
Hypertension
2.30
1.29-4.10
Bleeding per rectum
2.57
1.50-4.38
Internal hemorrhoids
1.96
1.06-3.65
Table 4 Factors associated with of bleeding per rectum in those with diverticulosis on univariable analysis, none of the variables were associated with bleeding per rectum on multivariable analysis
Variable
OR
95%CI
Age
1.00
0.97-1.02
Hypertension
0.73
0.27-1.95
Diabetes
1.27
0.48-3.32
Dyslipidemia
1.00
0.32-3.15
Atrial fibrillation
0.44
0.05-3.50
Abdominal Pain
0.19
0.07-0.57
Constipation
0.75
0.33-1.70
Diarrhea
0.39
0.04-3.38
Internal hemorrhoids
2.61
1.48-4.61
Polyps
1.28
0.72-2.29
Table 5 Findings on colonoscopy and possible etiologies for patients referred for bleeding per rectum
Etiology
Percentage
95%CI
Internal hemorrhoids
44.66%
40.36-48.96
Diverticulosis
33.60%
27.73-39.47
Mass
31.45%
26.03-36.87
Polyps
24.76%
21.37-28.15
Colitis
18.97%
14.44-23.49
Citation: Azzam N, Aljebreen AM, Alharbi O, Almadi MA. Prevalence and clinical features of colonic diverticulosis in a Middle Eastern population. World J Gastrointest Endosc 2013; 5(8): 391-397