Assessment of gastroesophageal reflux disease by serodiagnosis of Helicobacter pylori-related chronic gastritis stage

Table 1 Relationship between H.pylori infection or serum PG test and upper abdominal symb to ms erosive reflux esophagitis

	H.pylori infection		P value	Serum PG test		P value
	-	+		-	+
n	236	589		529	296
FSSG
-total score (mean ± SD)	3.58 ± 4.00	3.17 ± 3.90	0.175	3.45 ± 3.96	2.99 ± 3.87	0.104
-acid reflux score (mean ± SD)	1.78 ± 2.21	1.62 ± 2.32	0.350	1.79 ± 2.33	1.45 ± 2.20	0.038
-dysmotility score (mean ± SD)	1.80 ± 2.32	1.55 ± 1.99	0.127	1.66 ± 2.14	1.54 ± 2.02	0.432
Erosive esophagitis (LA grade A-D)	28.4%(67/236)	10.7%(63/589)	0.000	21.2%(112/529)	6.1%(18/296)	0.000
FSSG total score ≥ 8 (= GERD)	13.6%(32/236)	11.7%(69/589)	0.465	13.8%(73/529)	9.5%(28/296)	0.076
FSSG total score ≥ 8 and non-erosive esophagitis (= NERD)	8.1%(19/236)	9.5%(56/589)	0.510	9.8%(52/529)	7.8%(23/296)	0.377
NERD/GERD	59.4%(19/32)	81.2%(56/69)	0.027	71.2%(52/73)	82.1%(23/28)	0.317

H.pylori: Helicobacter pylori; PG: pepsinogen; CAG: chronic atrophic gastritis; FSSG: frequency scale for symptoms of gastroesophageal reflux disease; SD: standard deviation; LA: Los Angeles classification; GERD: gastroesophageal reflux disease; NERD: non-erosive reflux disease.

Table 2 Relationship between the stage of H.pylori-related chronic gasrtritis ang upper abdominal symptoms or erosive reflux esophagitis

Stages of H.pylori-related chronic gastritis	Group A	Group B	Group C	Group D	Overall P value
H.pylori infection	-	+	+	-
Serum PG test (extensive CAG)	-	-	+	+
n	219	310	279	17
Age (years: mean ± SD)	55.23 ± 4.23	55.84 ± 4.0	56.79 ± 3.91	53.94 ± 5.01	0.001
Sex (male/female)	214/5	308/2	273/6	17/0	0.306
Smokers	44.29%	35.16%	41.58%	41.18%	0.164
Drinkers	75.34%	75.48%	74.19%	70.59%	0.939
Serum PG I(ng/mL mean ± SD)	59.82 ± 26.52	81.76 ± 48.16	36.59 ± 18.42	21.98 ± 15.99	-
Serum PG II(ng/mL mean ± SD)	10.80 ± 5.81	25.89 ± 18.42	20.70 ± 8.60	12.89 ± 4.84	-
PG I/II	5.70 ± 1.13	3.74 ± 1.31	1.76 ± 0.69	1.53 ± 0.95	-
H.pylori Ig G Ab titer (U/mL mean ± SD)	13.54 ± 5.26	475.31 ± 632.73	441.07 ± 50.94	16.71 ± 6.44	-
FSSG
-total score (mean ± SD)	3.69 ± 4.01	3.33 ± 3.87	3.00 ± 3.94	2.88 ± 2.55	0.183
-acid reflux score (mean ± SD)	1.83 ± 2.26	1.77 ± 2.39	1.46 ± 2.25	1.29 ± 1.26	0.038
-dysmotility score (mean ± SD)	1.81 ± 2.37	1.56 ± 1.96	1.54 ± 2.03	1.59 ± 1.77	0.800
Erosive esophagitis (LA grade A-D)	30.6%(67/219	14.5%(45/310)	6.5%(18/279)	0%(0/17)	0.000
LA grade A/B/C/D	45/18/4/0	30/13/2/0	11/6/1/0	0/0/0/0	-
Hiatal hernia	3.2%(7/219)	5.8%(18/310)	7.2%(20/279)	5.9%(1/17)	0.231
FSSG total score ≥ 8 (=GERD)	14.6%(32/219)	13.2%(41/310)	9.7%(28/279)	0%(0/17)	0.177
FSSG total score ≥ 8 and non-erosive esophagitis (=NERD)	8.7%(19/219)	10.6%(33/310)	8.2%(23/279)	0%(0/17)	0.496
NERD/GERD	59.4%(19/32)	80.5%(33/41)	82.1%(23/28)	-	0.081

H.pylori:Helicobacter pylori; PG: pepsinogen; CAG: chronic atrophic gastritis; FSSG: frequency scale for symptoms of gastroesophageal reflux disease; SD: standard deviation; LA: Los Angeles classification; GERD: gastroesophageal reflux disease; NERD: non-erosive reflux disease.