Case Report
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastrointest Endosc. Dec 16, 2010; 2(12): 408-412
Published online Dec 16, 2010. doi: 10.4253/wjge.v2.i12.408
Table 1 Histological tumor grading proposed by Rindi et al[14]
Grade 1aTumors characterized by small and microlobular-trabecular aggregates formed by regularly distributed, often aligned cells with regular monomorphic nuclei, usually inapparent nucleoli, rather abundant fairly eosinophilic cytoplasm and almost absent mitoses.
Grade 1bTumors characterized by significant areas with solid structure, absence of cell alignment, round to spindle cell shape, irregular and moderately polymorphic nuclei of larger size, often with evident nucleoli and rather few, morphologically typical mitoses.
Grade 2Tumors showed prevalence of solid cellular aggregates and large trabeculae, crowding and irregular distribution of round to spindle and polyhedric tumor cells, fairly large vesicular nuclei with prominent eosinophilic nucleoli or smaller, hyperchromatic nuclei with irregular chromatin clumps and small nucleoli, considerable mitotic activity, sometimes with atypical mitotic figures and scant necrosis.
Grade 3Tumors showed severe histological atypia with solid to diffuse structure and frequent central necrosis. They were composed of tightly packed, small to mid-sized tumor cells showing large, irregular, polymorphic and hyperchromatic nuclei, scant cytoplasm and frequent, often atypical, mitosis.
Table 2 Clinicopathological characteristics of gastric carcinoid cases with hypergastrinemia successfully resected endoscopically or were followed-up only, published in Japan after the year (1995) of Gilligan's proposal
AuthorsAgeMale/FemaleGastrin (pg/mL)Anti-PCA/anti-IFANumber of tumorSize (mm)TreatmentTumor depthFollow-up length (mo)
Kawaguchi[26]33-69110/374-2100NA/NA1 or multipleNAEMRNANA
Hosokawa[29]46-6913/5442-3800(+) in 7/NAmultiple1-15follow-up onlyNA18-130
Higashino[30]34-7813/3195-1800NA/NA1 or 20.732EMRm, sm4-78
Ichikawa[31]35-6613/1319-1122(+) in 3/(+) in 113-8EMRm, sm6-56
Shimazu[32]650/13400(+)/NA95EMR or hot biopsym48
Hori[34]511/0> 800(+)/NA17EMRm144