Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

Table 1 Baseline patient characteristics before and after propensity score matching

Characteristics	Before propensity score matching			After propensity score matching
	LC group (n = 589)	EGPS group (n = 73)	P value	LC group (n = 40)	EGPS group (n = 40)	P value
Sex			0.576			0.251
Male	205	23		18	13
Female	384	50		22	27
Age	52 (41, 60)	43 (33, 52)	0.000	43 ± 12	44 ± 11	0.817
BMI	25 (23, 28)	22 (20, 25)	0.267	25 ± 4	25 ± 3	0.681
Number of gallstones			0.355			0.644
Single	199	26		16	14
Multiple	390	47		24	26
Preoperative CGIQLI score	130 (127, 132)	135 (133, 137)	0.000	134 (131, 136)	133 (132, 135)	0.526
Physical well-being	35 (34, 37)	37 (35.5, 38)	0.000	37 (35, 38)	36 (35, 37)	0.345
Mental well-being	17 (16, 17)	19 (19, 20)	0.000	19 (19, 19)	19(19, 19)	0.690
Gastrointestinal digestion	35 (34, 36)	36 (34, 37)	0.000	35 (34, 36)	35 (34, 36)	0.692
Gastrointestinal defecation	23 (22, 24)	24 (24, 24)	0.003	24 (23, 24)	24 (24, 24)	0.653
Follow-up time	692 (544, 842)	676 (590, 810)	0.610	718 (488, 898)	747 ± 154	0.256

BMI: body mass index; CGIQLI: Gastrointestinal Quality of Life Index; EGPS: Endoscopic gallbladder-preserving surgery; LC: Laparoscopic cholecystectomy.

Table 2 Hospital stay, surgery duration, cost and short-term adverse events in laparoscopic cholecystectomy and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery treatment groups

	LC group (n = 589)	EGPS group (n = 73)	P value
Hospital stay (d)	5 (3, 7)	8 (7, 10)	0.000
Surgery duration (min)	67 (50, 95)	100 (85, 117)	0.000
Cost (RMB)	18421 (15532, 21311)	24084 ± 5740	0.000
Short-term adverse event	3	1	0.374

EGPS: Endoscopic gallbladder-preserving surgery; LC: Laparoscopic cholecystectomy.

Table 3 Comparison of preoperative and postoperative scores

	Preoperative	Postoperative	P value
EGPS group
Total CGIQLI score	133 (132, 135)	141 (140, 142)	0.000
Physical well-being	36 (35, 37)	40 (40, 40)	0.000
Mental well-being	19(19, 19)	20 (20, 20)	0.000
Gastrointestinal digestion	35 (34, 36)	38 (37, 38)	0.000
Gastrointestinal defecation	24 (24, 24)	24 (24, 24)	0.603
LC group
Total CGIQLI score	134 (131, 136)	140 (137, 142)	0.001
Physical well-being	37 (35, 38)	40 (39, 40)	0.000
Mental well-being	19 (19, 19)	20 (19, 20)	0.081
Gastrointestinal digestion	35 (34, 36)	38 (37, 39)	0.000
Gastrointestinal defecation	24 (23, 24)	24 (23, 24)	0.004

CGIQLI: Gastrointestinal Quality of Life Index; EGPS: Endoscopic gallbladder-preserving surgery; LC: Laparoscopic cholecystectomy.

Table 4 Comparison between postoperative groups

	EGPS group	LC group	P value
Preoperative total CGIQLI score	134 (131, 136)	133 (132, 135)	0.526
Physical well-being	37 (35, 38)	36 (35, 37)	0.345
Mental well-being	19 (19, 19)	19(19, 19)	0.690
Gastrointestinal digestion	35 (34, 36)	35 (34, 36)	0.692
Gastrointestinal defecation	24 (23, 24)	24 (24, 24)	0.653
Postoperative total CGIQLI score	141 (140, 142)	140 (137, 142)	0.063
Physical well-being	40 (40, 40)	40 (39, 40)	0.094
Mental well-being	20 (20, 20)	20 (19, 20)	0.253
Gastrointestinal digestion	38 (37, 38)	38 (37, 39)	0.685
Gastrointestinal defecation	24 (24, 24)	24 (23, 24)	0.002

CGIQLI: Gastrointestinal Quality of Life Index; EGPS: Endoscopic gallbladder-preserving surgery; LC: Laparoscopic cholecystectomy.

Table 5 Analysis of recurrence factors after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

	No recurrence group (n = 67)	Recurrence group (n = 6)	P value
Sex			0.371
Male	20	3
Female	47	3
Age	42 (33, 51)	50.8 ± 11.4	0.074
BMI	25.0 ± 3.6	25.5 ± 1.9	0.730
Number of gallstones			1.000
Single	24	2
Multiple	43	4
Preoperative total CGIQLI score	135 (133, 137)	136.5 ± 11.7	0.163

BMI: Body mass index; CGIQLI: Gastrointestinal Quality of Life Index.