Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding: Meta-analysis of randomized controlled trials

Table 1 Main characteristics of the included studies in the systematic review and meta-analysis

No.	Ref.	Country	Year of publication	Study design	Number of participants in SLE	Number of participants in No SLE	GIB symptoms in SLE total	GIB symptoms In No SLE total	Timing of SLE	Risk factors for the occurrence of post-procedural bleeding
Endoscopic submucosal dissection for gastric neoplasm
1	Ryu et al[15]	Korea	2013	Prospective, randomized, controlled trial study	74	81	15	11	> 24 h	Longer procedure: (41.4 ± 28.2 min vs 32.1 ± 25.8 min; P < 0.048)
2	Kim et al[16]	Korea	2014	Prospective, randomized, single-blind, controlled trial	220	217	8	6	> 48 h	Large tumor size > 20 mm
3	Mochizuki et al[17]	Japan	2015	Multicenter prospective randomized controlled non-inferiority trial	130	132	7	5	> 24 h	Large tumor size > 40 mm
4	Jee et al[18]	Korea	2016	Multicenter prospective randomized-controlled study	110	110	7	2	> 24 h	Ulcerative lesions finding
Peptic ulcer bleeding
1	Chiu et al[19]	China	2003	Single center, prospective, randomized, controlled trial	100	94	5	13	16-24 h	N/A
2	Chiu et al[20]	China	2016	Single center, prospective, randomized, controlled trial	152	153	12	10	16-24 h	Baylor bleeding score
3	Park et al[21]	Japan	2018	Multicenter, prospective, randomized, controlled trial	158	161	16	9	24 to 36 h	N/A
4	Pittayanon et al[22]	Hong Kong	2022	Multicenter, prospective, randomized, controlled trial	75	76	9	14	24 h	N/A
5	Villanueva et al[23]	Spain	1994	Prospective, randomized, controlled trial	52	52	11	15	24 h	N/A
6	Messmann et al[24]	Germany	1998	Multicenter, prospective, randomized, controlled trial	52	53	14	11	16-24 h	N/A
7	Saeed et al[25]	United States	1996	Single-center, prospective, randomized, controlled trial	19	21	0	5	24 h	Active bleeding, visible vessel, fresh adherent clot
8	Lee[26]	-	2005	Randomized, controlled trial	70	73	7	12	-	NA

SLE: Second-look endoscopy.