Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis

Table 1 Preoperative data of ten children

Case	Sex	Age (yr)	Risk grading	Interval between first AAP onset and ERCP (mo)	Clinical features	Nasal jejunal tube	Number of AAP onsets (times)	Weight loss (kg)
1	Female	4	Medium	4	Abdominal pain, vomiting, inability to eat	Yes	6	2
2	Male	10	Medium	3	Abdominal pain, vomiting, inability to eat	Yes	4	6
3	Male	12	Medium	3	Abdominal pain, vomiting, inability to eat	Yes	7	7
4	Male	6	Low	6	Abdominal pain, vomiting, inability to eat	Yes	9	4
5	Female	13	Medium	3	Abdominal pain, vomiting, inability to eat	Yes	5	2
6	Male	4	Medium	3	Abdominal pain, vomiting, inability to eat	No	5	3
7	Female	4	Medium	6	Abdominal pain, vomiting, inability to eat	Yes	9	3
8	Male	7	Medium	3	Abdominal pain, inability to eat	Yes	2	7
9	Female	7	Medium	8	Abdominal pain, vomiting, inability to eat	No	9	3
10	Female	4	Medium	4	Abdominal pain, vomiting, inability to eat	No	5	3

AAP: Asparaginase-associated pancreatitis; ERCP: Endoscopic retrograde cholangiopancreatography.

Table 2 Status of endoscopic retrograde cholangiopancreatography operation

Case	Presence of pseudocyst and its size (mm)	Pancreatic duct stenosis	Pancreatic duct stones	ERCP operation mode	ERCP operation times
1	40 × 15	No	Yes	EPS+ERPD	2
2	/	No	Yes	EPS+balloon manipulation	1
3	81 × 41	Yes	No	Balloon manipulation +ERPD	1
4	/	Yes	Yes	EPS+ERPD	2
5	68 × 40	Yes	No	Balloon manipulation+EPS+ERPD	1
6	16 × 12	No	No	EST	1
7	/	No	Yes	Balloon manipulation+ERPD	1
8	48 × 40	Yes	No	Balloon manipulation+EPS+ERPD	1
9	/	No	Yes	EPS	1
10	/	No	Yes	EPS+ERPD	1

EPS: Endoscopic pancreatography sphincterotomy; EST: Endoscopic sphincterotomy; ERPD: Endoscopic retrograde pancreatic drainage; ERCP: Endoscopic retrograde cholangiopancreatography.

Table 3 Follow-up data of the seven children

Case	Ultrasonography for pseudocyst	After ERCP acute pancreatitis onsets (times)	Clinical symptoms	Postoperative complications	Weight gain/yr (kg)
1	At 6 mo after the operation, no pseudocyst was found by ultrasonography	0	Abdominal pain disappeared, able to eat	No	5
2	/	0	Abdominal pain disappeared, able to eat	Postoperative pancreatitis	5
3	At 3 mo after the operation, no pseudocyst was found by ultrasonography	0	Abdominal pain disappeared, able to eat	Infection	8
4	/	0	Abdominal pain disappeared, able to eat	Infection	7
5	At 4 mo after the operation, ultrasonography revealed that the pseudocyst had disappeared	0	Abdominal pain disappeared, able to eat	No	3
6	There was still a 16 mm × 12 mm pseudocyst	0	Abdominal pain disappeared, able to eat	No	7
7	/	0	Abdominal pain disappeared, able to eat	No	1.5
8	At 2 mo after the operation, no pseudocyst was found by ultrasonography	0	Abdominal pain disappeared, able to eat	No	2
9	/	3	Abdominal pain, but did not affect eating	No	2
10	/	0	Abdominal pain disappeared, able to eat	No	3

ERCP: Endoscopic retrograde cholangiopancreatography.