Systematic Reviews
Copyright ©The Author(s) 2022.
World J Gastrointest Endosc. Jul 16, 2022; 14(7): 443-454
Published online Jul 16, 2022. doi: 10.4253/wjge.v14.i7.443
Table 1 Risk of Bias assessment [risk of bias assessment using the Revised Cochrane risk-of-bias for randomised trials (RoB 2.0)]
Random sequence generation
Allocation concealment
Blinding of participants and personnel
Blinding of outcome assessment
Incomplete outcome data
Selective reporting
Other bias
Bang et al[11]++-?++-
van Brunschot et al[28]++-+++-
Hollemans et al[30]+---++-
Table 2 Risk of Bias assessment [risk of bias assessment using the Revised Cochrane risk-of-bias for randomised trials (RoB 2.0)]
Selection bias
Bias in classification of interventions
Bias due to deviation from intended interventions
Incomplete outcome data
Blinding of outcome assessment
Selective reporting
Other bias
Seifert et al[27]--+++-+-
Smith et al[33]++??--+-
Cinquepalmi et al[17]?+++--+-
Fenton-Lee et al[29]+-?++---
Kriwanek et al[32]??-?+-+-
Reszetow et al[31]+?+++-+-
Broome et al[16]-?+---+-
Tu et al[34]?+?++-+-
Table 3 Study characteristics
Study design
Study interval
Patient cohort
Relevant patients
Patients in study
Assessment times
Broome et al[16], 1996 USADuke University of Medical CentreRetrospective with prospective follow-up1988 to 1994Surgery (operative debridement of necrosis)Pancreatic necrosis40 surgically managed patients with pancreatic necrosis40SF-36Average follow-up 51 mo
Fenton-Lee et al[29], 1993UKGreater Glasgow Health BoardProspectiveApril 1991 to March 1992Surgery (required operative intervention); 9/10 also received endoscopic proceduresPancreatic necrosis10; 10 operative intervention, 9/10 also endoscopic intervention10Rosser disability and distress indexAdmission and follow-up
Kriwanek et al[32], 1998AustriaRudolfstiftung-HospitalProspectiveJanuary 1 1988 to June 30 1996Surgery (open necrosectomy)Pancreatic necrosis75; 57 survivors75 with pancreatic necrosis (72 other sources of intra-abdominal infection)SF-36Not stated
Cinquepalmi et al[17], 2006ItalyNot reportedProspective1990 to 2005Surgery (sequential surgical debridement)Infected pancreatic necrosis35; all received sequential surgical debridement35SF-36Not reported
Reszetow et al[31], 2007PolandMedical University of GdańskProspectiveJanuary 1993 to December 1999Surgery (Bradley procedure)Infected pancreatic necrosis28; 44 (16.1%) of 274 patients with acute pancreatitis; 35/44 (63.4%) survivors for follow-up; 5 excluded44Functional Assessment of Chronic Illness Therapy scale24-96 mo
Seifert et al[27], 2009Germany6 centresRetrospective with prospective follow-up1999 to 2005, follow-up 2004 to 2008Endoscopy vs surgeryInfected pancreatic necrosis93; 75 endoscopic; 18 failed, 11 surgery93Study-specific toolUp to 24 mo
van Brunschot et al[28], 2017Netherlands19 centresRandomized trialSeptember 20 2011 to January 29 2015Endoscopy vs surgeryConfirmed or suspected infected pancreatic or peripancreatic necrosis.98; 51 endoscopic and 47 surgical98EQ-5D-3L3 and 6 mo
Hollemans et al[30], 2019 NetherlandsRandomized trialNovember 2005 to October 2008Surgery (step-up approach (primary percutaneous catheter drainage, followed by, if necessary, minimally invasive retroperitneal necrosectomy) vs open necrosectomyConfirmed or suspected infected pancreatic necrosis.60; 28/43 step-up approach (8 died), 32/45 open necrosectomy (7 died)88SF-36 and EuroQol3, 6, and 12 mo after discharge
Smith et al[33], 2019 USABarnes-Jewish Hospital/Washington University School of MedicineRetrospective with prospective follow-upJanuary 2006 to May 2016EndoscopyWalled off necrosis41 (returned QoL questionnaires)98SF-36Mean 37.4 (range 1-139) mo
Bang et al[11], 2020USAFlorida HospitalRandomized trialMay 12 2014 to March 24 2017Endoscopy vs surgeryConfirmed or suspected infected pancreatic or peripancreatic necrosis.66; 34 endoscopic and 32 surgery66SF-363 and 6 mo
Tu et al[34], 2020ChinaJinling Hospital, Medical School of Nanjing UniversityRetrospective with prospective follow-upJanuary 2000 to February 2015Surgery (open necrosectomy) vs minimally invasive drainageInfected pancreatic necrosis109; 101 included in analysis (61 minimally invasive drainage, 40 open necrosectomy)109SF-36Not stated