Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer

Table 1 Endoscopic gastritis based on Kyoto classification of Helicobacter pylori-infected patients with vs without gastric cancer

	Gastric cancer (+)	Cancer (-)	Univariate analysis			Multivariate analysis
			Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
n	132	367
Age, mean (SD), yr	66.4 (12.4)	50.9 (12.4)	1.099	1.078-1.120	< 0.001
Age ≥ 65 yr, %	60.6	15.3	8.544	5.446-13.405	< 0.001	4.010	2.436-6.603	< 0.001
Male sex, %	55.3	47.7	1.357	0.910-2.024	0.134
Atrophy score, mean (SD)	1.871 (0.336)	1.411 (0.642)	6.173	3.635-10.486	< 0.001	2.800	1.583-4.954	< 0.001
Intestinal metaplasia score, mean (SD)	1.402 (0.809)	0.624 (0.878)	2.570	2.031-3.253	< 0.001	1.567	1.188-2.067	0.001
Enlarged folds score, mean (SD)	0.364 (0.483)	0.441 (0.497)	0.723	0.480-1.090	0.121
Nodularity score, mean (SD)	0.152 (0.360)	0.387 (0.488)	0.283	0.168-0.476	< 0.001	0.508	0.282-0.913	0.024
Diffuse redness score, mean (SD)	1.841 (0.507)	1.823 (0.466)	1.085	0.706-1.667	0.709
Kyoto score, mean (SD)	5.629 (1.149)	4.687 (1.637)	1.568	1.342-1.831	< 0.001

P value was calculated using the binomial logistic regression analysis. CI: Confidence interval; SD: Standard deviation.

Table 2 Endoscopic gastritis based on Kyoto classification of Helicobacter pylori-infected patients with diffuse-type gastric cancer vs without gastric cancer

	Diffuse-type cancer (+)	Cancer (-)	Univariate analysis			Multivariate analysis
			Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
n	39	367
Age, mean (SD), yr	58.00 (13.00)	50.88 (12.41)	1.044	1.018-1.072	0.001
Age ≥ 65 yr, %	28.2	15.3	2.182	1.027-4.634	0.042	1.434	0.633-3.246	0.388
Male sex, %	38.5	47.7	0.686	0.348-1.349	0.275
Atrophy score, mean (SD)	1.692 (0.468)	1.411 (0.642)	2.327	1.223-4.428	0.010	2.327	1.223-4.428	0.010
Intestinal metaplasia score, mean (SD)	0.974 (0.903)	0.624 (0.878)	1.516	1.065-2.158	0.021	1.313	0.905-1.906	0.152
Enlarged folds score, mean (SD)	0.564 (0.502)	0.441 (0.497)	1.638	0.842-3.186	0.146
Nodularity score, mean (SD)	0.282 (0.456)	0.387 (0.488)	0.622	0.300-1.290	0.202
Diffuse redness score, mean (SD)	1.821 (0.556)	1.823 (0.466)	0.990	0.495-1.978	0.976
Kyoto score, mean (SD)	5.333 (1.402)	4.687 (1.637)	1.306	1.044-1.632	0.019

P value was calculated using the binomial logistic regression analysis. CI: Confidence interval; SD: Standard deviation.

Table 3 Endoscopic gastritis based on Kyoto classification of Helicobacter pylori-infected patients with intestinal-type gastric cancer vs without gastric cancer

	Intestinal-type cancer (+)	Cancer (-)	Univariate analysis			Multivariate analysis
			Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
n	93	367
Age, mean (SD), yr	69.86 (10.29)	50.88 (12.41)	1.138	1.107-1.169	< 0.001
Age ≥ 65 yr, %	74.2	15.3	15.967	9.261-27.527	< 0.001	6.220	3.394-11.400	< 0.001
Male sex, %	62.4	47.7	1.818	1.140-2.900	0.012	1.794	0.955-3.372	0.069
Atrophy score, mean (SD)	1.946 (0.227)	1.411 (0.642)	15.312	6.147-38.144	< 0.001	6.167	2.321-16.382	< 0.001
Intestinal metaplasia score, mean (SD)	1.581 (0.697)	0.624 (0.878)	3.368	2.499-4.539	< 0.001	1.683	1.166-2.430	0.005
Enlarged folds score, mean (SD)	0.280 (0.451)	0.441 (0.497)	0.491	0.299-0.808	0.005	0.453	0.237-0.867	0.017
Nodularity score, mean (SD)	0.097 (0.297)	0.387 (0.488)	0.170	0.083-0.348	< 0.001	0.323	0.141-0.742	0.008
Diffuse redness score, mean (SD)	1.849 (0.488)	1.823 (0.466)	1.135	0.681-1.891	0.626
Kyoto score, mean (SD)	5.753 (1.007)	4.687 (1.637)	1.696	1.407-2.004	< 0.001

P value was calculated using the binomial logistic regression analysis. CI: Confidence interval; SD: Standard deviation.

Table 4 Endoscopic gastritis based on Kyoto classification of Helicobacter pylori-infected patients with diffuse- vs intestinal-type gastric cancer

	Diffuse-type	Intestinal-type	Univariate analysis			Multivariate analysis
			Odds ratio	95%CI	P value	Coefficient	95%CI	Odds ratio	95%CI	P value
n	39	93
Age, mean (SD), yr	58.00 (13.00)	69.86 (10.29)	1.091	1.051-1.132	< 0.001
Age ≥ 65 yr, %	28.2	74.2	7.318	3.166-16.917	< 0.001	1.983	1.045, 2.921	7.263	2.843-18.553	< 0.001
Male sex, %	38.5	62.4	2.651	1.228-5.724	0.013	1.021	0.069, 1.973	2.776	1.071-7.193	0.036
Atrophy score, mean (SD)	1.692 (0.468)	1.946 (0.227)	7.822	2.530-24.188	< 0.001	0.727	-0.927, 2.381	2.069	0.396-10.816	0.389
Intestinal metaplasia score, mean (SD)	0.974 (0.903)	1.581 (0.697)	2.473	1.544-3.959	< 0.001	0.678	0.128, 1.228	1.970	1.136-3.413	0.016
Enlarged folds score, mean (SD)	0.564 (0.502)	0.280 (0.451)	0.300	0.138-0.653	0.002	-1.308	-2.261, -0.356	0.270	0.104-0.701	0.007
Nodularity score, mean (SD)	0.282 (0.456)	0.097 (0.297)	0.273	0.102-0.726	0.009	-0.237	-1.621, 1.147	0.789	0.198-3.149	0.737
Diffuse redness score, mean (SD)	1.821 (0.556)	1.849 (0.488)	1.116	0.545-2.288	0.764
Kyoto score, mean (SD)	5.333 (1.402)	5.753 (1.007)	1.355	0.987-1.860	0.060

P value was calculated using the binomial logistic regression analysis. CI: Confidence interval; SD: Standard deviation.