Should a colonoscopy be offered routinely to patients with CT proven acute diverticulitis? A retrospective cohort study and meta-analysis of best available evidence

Table 1 The outcomes in diverticulitis and screening groups

	Diverticulitis group	Screening group	P-value
Total number of patients	68	1309	-
Mean age	59.1(55.67- 62.4)	55.4 (55.1, 55.7)	< 0.001
Male patients	35 of 68 (51.5%)	694 out of 1309	0.94
Patients with adenoma	4 out of 68 (5.9%)	100 out of 1309 (7.6%)	0.59
Patients with non-advanced adenoma	4 out of 68 (5.9%)	90 out of 1309 (6.9%)	0.75
Patients with advanced adenoma	0 out of 68 (0%)	10 out of 1309 (0.8%)	1
Patients with low-risk adenoma	4 out of 68 (5.9%)	84 out of 1309 (6.4%)	0.86
Patients with intermediate-risk adenoma	0 out of 68 (0%)	12 out of 1309 (0.92%)	1
Patients with high-risk adenoma	0 out of 68 (0%)	4 out of 1309 (0.31%)	1
Patients with cancers	0 out of 68 (0%)	2 out of 1309 (0.15%)	1
Patients with polyps	11 out of 68 (16.2%)	186 out of 1309 (14.2%)	0.65
Patients with hyperplastic polyps	6 out of 68 (8.8%)	60 out of 1309 (4.6%)	0.11
Patients with unbiopsied polyps	1 out of 68 (1.5%)	24 out of 1309 (1.8%)	0.83

Table 2 Baseline characteristics of the included studies in the meta-analysis

Ref.	Year	Country	Journal	Design	Descrip-tion of diverticuli-tis group	Descrip-tion of control group	How diverticuli-tis is diagnosed	Time from diagnosis to endoscopy	Sample size
									Diverticuli-tis group	Screening group
Current study	2018	United Kingdom	Not applicable	Retrospec-tive observation-al	Patients undergoing a colonoscopy after medical treatment of CT proven diverticulitis	Individuals from the general population undergoing flexible sigmoidos-copy for screening purposes at age of 55	Computed tomography	up to 12 mo	68	1309
Daniels et al[16]	2014	The Netherlands	Surg Endosc	Retrospec-tive observation-al	Patients undergoing a colonoscopy after medical treatment of CT proven diverticulitis	Individuals from the general population between the age of 50-75 undergoing screening colonoscopy	Computed tomography	up to 6 mo	401	1426
Lecleire et al[17]	2014	France	United European Gastroenterol J	Retrospec-tive observation-al	Patients undergoing a colonoscopy after medical treatment of CT proven diverticulitis	Asymptomatic patients undergoing a screening colonoscopy	Computed tomography	up to 6 mo	404	404
Choi et al[24]	2014	South Korea	Dig Dis Sci	Retrospec-tive observation-al	Patients undergoing a colonoscopy after medical treatment of CT proven diverticulitis	Healthy individuals undergoing screening colonoscopy	Computed tomography	up to 12 mo	149	298