Role of colonoscopy in diagnosis of capecitabine associated ileitis: Two case reports

Table 1 Colonoscopy and histology reports from previous case reports of capecitabine associated ileitis

Case report	Findings seen on (1) colonoscopy and (2) histology
Barton[6], 2006	(1) Ulcerative ileitis (2) Eosinophilic infiltrates
Al-Gahmi et al[7], 2012	(1) Isolated ulceration in the terminal ileum (2) Inflammatory changes and eosinophilic infiltrate but no evidence of malignancy or granulomas
Mokrim et al[8], 2014	(1) Inflammatory changes in the ileal mucosa (2) Absence of intraepithelial lymphocytic infiltrates in favour of a non-atrophic ileitis
Van Hellemond et al[9], 2018	Terminal ileitis Extensive inflammation of the small intestine
Case 1	(1) Evidence of granular erythematous mucosa with ulceration both above and below the ileocolonic anastomosis in the terminal ileum and ascending colon(2) Mucosal erosion with acute and chronic inflammation and occasional atypical glands most likely representing reactive changes without evidence of Cytomegalovirus or herpes simplex viruses on immunohistochemical stains
Case 2	(1) On colonoscopy, the terminal ileum was found to have diffuse pseudomembranes with severe inflammatory exudates and spontaneous bleeding.(2) Necrotic and inflammatory debris, but was negative for granulomas or viral inclusions.