Treatment of high-grade dysplasia and intramucosal carcinoma using radiofrequency ablation or endoscopic mucosal resection + radiofrequency ablation: Meta-analysis and systematic review

Table 1 Characteristics of the studies included in the endoscopic mucosal resection + radiofrequency ablation arms vs radiofrequency ablation alone

Ref.	Country	Centers	Type of study	Subjects (EMR + RFA/RFA alone	Outcomes
Li et al[10], 2015	USA	148	Observational retrospective	1263 (406/857)	Efficacy and safety
Strauss et al[11], 2014	USA	2	Observational retrospective	36 (31/5)	Efficacy and safety
Haidry et al[12], 2013	England	19	Observational retrospective	335 (164/171)	Efficacy and safety
Kim et al[14], 2012	USA	1	Observational retrospective	169 (65/104)	Efficacy and safety
Caillol et al[15], 2012	France	1	Observational retrospective	34 (16/18)	Efficacy and safety
Okoro et al[16], 2012	USA	1	Observational retrospective	100 (44/46)	Efficacy and safety
Pouw et al[17], 2008	The Netherlands	1	Observational retrospective	44 (31/13)	Efficacy and safety

EMR: Endoscopic mucosal resection; RFA: Radiofrequency ablation.

Table 2 Newcastle-Ottawa Scale for evaluating the quality of the studies

Ref.	Selection				Comparability	Outcome			Points
	Representativeness of the exposed cohort	Selection of the unexposed cohort	Ascertainment of exposure	Demonstration that outcome of interest was not present at the start of study	Comparability of cohorts on the basis of the design or analysis	Assessment of outcome	Was follow-up long enough for outcomes to occur	Adequacy of follow-up of cohort
Li et al[10], 2015	×	×	×	×	×	×	×		7 Points
Strauss et al[11], 2014	×	×	×	×	×	×	×	×	8 Points
Haidry et al[12], 2013	×	×	×	×	×	×		×	7 Points
Kim et al[14], 2012	×	×	×	×	×	×			6 Points
Caillol et al[15], 2012	×	×	×	×		×		×	6 Points
Okoro et al[16], 2012	×	×	×	×	×	×		×	7 Points
Pouw et al[17], 2008	×	×	×	×	××	×		×	8 Points

Table 3 Endoscopic resection and residual Barrett’s esophagus diagnosis methods

Ref.	Endoscopic resection method	Residual BE diagnosis method
Li et al[10], 2015	Not mentioned	Not mentioned
Strauss et al[11], 2014	Duette device	Not mentioned
Haidry et al[12], 2013	Duette device	Not mentioned
Kim et al[14], 2012	ER-cap technique (Olympus) (55%); Duette device (45%)	NBI assisted
Caillol et al[15], 2012	Duette device or double channel technique	Staining with acetic acid or high definition endoscopy
Okoro et al[16], 2012	ER-cap technique (Olympus) and Duette device*	Not mentioned
Pouw et al[17], 2008	ER-cap technique (Olympus) and Duette device*	Lugol’s staining (2%) or narrow-band imaging1

¹Authors did not mention which method was used. BE: Barrett’s esophagus.