Randomised controlled trial comparing modified Sano’s and narrow band imaging international colorectal endoscopic classifications for colorectal lesions

Table 1 Narrow band imaging international colorectal endoscopic classification of colorectal polyps was based on 3 features including colour, vessel, architecture and surface pattern

	NICE I	NICE II	NICE III
Colour	Same or lighter than background	Browner than background	Dark brown relative to background +/- patchy whiter areas
Vessels	None or isolated lacy vessels	Brown vessels surrounding white structures	Disrupted or missing vessels
Surface pattern	Dark or white spots of uniform size, or homogeneous absence of pattern	Oval, tubular or branched white structure surrounded by brown vessels	Amorphous or absent surface pattern
Likely pathology	Hyperplastic	Adenoma	Deep submucosal invasive cancer

NICE: Narrow band imaging international colorectal endoscopic.

Table 2 Demographics of study participants

Classification	Modified Sano’s	NICE	P value
age (mean ± SD)	62.18 ± 14.06	64.41 ± 11.36	NS
M:F (% male)	191:118 (62%)	178:76 (70%)	NS
Indication n (%)
Screening	156 (50)	115 (45)	NS
Surveillance	86 (28)	88 (35)
Symptoms	63 (20)	49 (19)
Others	4 (1)	2 (1)
Total	309	254

NICE: Narrow band imaging international colorectal endoscopic; NS: Non-significant.

Table 3 Characteristics of colon polyps

Classification	Modified Sano’s	NICE	P value
Confidence level n (%)
High	309 (96.3)	254 (78)	<0.0001
Low	12 (3.7)	72 (22)
Total	321	326
Distribution based on size
≤ 5 mm	151	127	NS
6-9 mm	63	42
≥ 10 mm	95	85
Size (mean ± SD, mm)	10.17 ± 11.30	14.48 ± 19.47	0.0036
Polyp distribution n (%)
Right colon	95 (31)	101 (40)	NS
Transverse colon	60 (19)	52 (20)
Descending colon	34 (11)	27 (11)
Rectosigmoid colon	120 (39)	74 (29)
Total	309	254
Paris n (%)
1p	28 (9)	18 (7)	NS
1s	190 (61)	156 (61)
2a	81 (26)	71 (28)
2b	4 (1)	1 (1)
2c	5 (2)	6 (2)
3	1 (1)	2 (1)
Others	12	15
Total	309	254

NICE: Narrow band imaging international colorectal endoscopic; NS: Non-significant.

Table 4 Accuracy of modified sano’s IIo class for sessile serrated adenoma/polyp

	SSA/P	Other histology
MS IIo	43 (13)	5 (1.54)
Other MS classification	4 (1.23)1	273 (84)

¹SSA/P histology was correlated with either I or IIo on MS. SSA/P: Sessile serrated adenoma/polyp; MS: Modified Sano’s.

Table 5 Results of in vivo prediction for post-polypectomy surveillance interval

	Modified Sano’s	NICE
Total patients	175	173
Accurate	167	139
Overcalled1	2	8
Undercalled2	1	4
Excluded	5	22

¹Surveillance colonoscopy interval prediction with classification was premature compared to the determined by final histology;

²Surveillance colonoscopy interval prediction with classification was delayed compared to the determined by final histology. NICE: Narrow band imaging international colorectal endoscopic.