Pancreatic cystic lesions: How endoscopic ultrasound morphology and endoscopic ultrasound fine needle aspiration help unlock the diagnostic puzzle

Figure 1 Serous cystoadenoma. A: Microcystic area, centrally located; B: Beside microcystic area; C: Peripheral and internal septa microcystic area, lobulate contour; D: Pseudosolid form.

Figure 2 Mucinous cystic neoplasm. A-B: Round lesions with septa (aspects of cysts in cyst with round contour).

Figure 3 Branch duct intraductal papillary mucinous neoplasm. A: “Bunch of grapes” lesion (cysts by cyst aspects with irregular contour); B: Finger-like aspect; C: Clubbed-like aspect.

Figure 4 Pancreatic pseudocyst. Round lesion without septa and with visible hyperechoic debris inside.

Figure 5 Unilocular aspects in cystic pancreatic lesions. A: Sixty year old female, no symptoms. Lesion in pancreatic head, no visible communication with pancreatic duct. Carcinoembryonic antigen (CEA) 1.5 ng/mL, Amylase 125 U/L, K-RAS mutations negative. Cytology: Cuboidal cell periodic acid-Schiff positive, no mucus. Diagnosis: Unilocular serous cystoadenoma; B: Seventy-nine year old female, no symptoms. Multiple cystic lesion in pancreatic head and tail. Lesion in pancreatic tail with visible communication with pancreatic duct. CEA 12 000 ng/mL, amylase 12 870 U/L, K-RAS mutation positive. Cytology: Mucin and cuboidal cell with mild atypia and papillary arrangement. Diagnosis: Multifocal branch ducts-intraductal papillary mucinous neoplasm; C: Fifty year old female. Lesion in pancreatic body, no visible communication with pancreatic duct. CEA 280 ng/mL, amylase > 15 000 U/L, K-RAS mutation positive. Cytology: Acellular without mucin. Surgical histology: Mucinous cystoadenoma; D: Forty-five year old male, history of alcoholism and recurrent acute pancreatitis. Lesion in pancreatic body. CEA 61 ng/mL, amylase > 15 000 U/L, K-RAS mutations negative. Cytology: Inflammatory cells and pigmented histocytes. Diagnosis: Pancreatic pseudocyst.