Comparative efficacy and safety between endoscopic submucosal dissection, surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

Figure 1 Overall survival and recurrence-free survival of endoscopic submucosal dissection, surgery and definitive chemoradiotherapy before and after inverse probability of treatment weighting analysis. The small table in the figure represents the results obtained from a two-by-two comparison of the survival rates of the three groups. A: Survival curves of overall survival (OS) for patients before inverse probability of treatment weighting (IPTW) adjustment; B: Survival curves of recurrence-free survival (RFS) for patients before IPTW adjustment; C: Survival curves of OS for patients after IPTW adjustment; D: Survival curves of RFS for patients after IPTW adjustment. d-CRT: Definitive chemoradiotherapy; ESD: Endoscopic submucosal dissection. P value was calculated by the log-rank test.

Figure 2 Cox regression estimates of overall survival and recurrence-free survival after inverse probability of treatment weighting analysis among patients with cT1N0M0 EC who underwent endoscopic submucosal dissection, surgery and definitive chemoradiotherapy. A: Multivariate analysis showed that treatment method, histology and depth of infiltration were independently associated with overall survival; B: Multivariate analysis showed that treatment method, histology and depth of infiltration were independently associated with recurrence-free survival (RFS). CR: Complete response. (^*) represents the significant difference, and the more the number of “^a”, the greater the difference.