Limited validity of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis

Figure 1 Mayo endoscopic subscore, Nancy histological index and inflammation grade of primary sclerosing cholangitis-ulcerative colitis and ulcerative colitis patients in the cecum, rectum and ileum. ‘Cecum and rectum’ panels represent only the most severely affected lesions for each patient. The numbers of patients per grade are indicated in the graph. PSC-UC: Primary sclerosing cholangitis-ulcerative colitis.

Figure 2 Nancy histological index scores of primary sclerosing cholangitis-ulcerative colitis patients with Mayo endoscopic subscore grade 0 (top panels), Mayo endoscopic subscore grade 1 (middle panels) and Mayo endoscopic subscore grade 2 in the cecum and rectum. ‘Cecum and rectum’ panels represent only the most severely affected lesions for each patient. The numbers of patients per grade are indicated in the graph. MES: Mayo endoscopic subscore.

Figure 3 Hematoxylin-eosin stained cecal biopsies from primary sclerosing cholangitis-ulcerative colitis patients with Mayo endoscopic subscore grade 0, Mayo endoscopic subscore grade 1, and Mayo endoscopic subscore grade 2. A-D: All samples show an active colitic pattern with numerous neutrophils infiltrated into lamina propria and epithelium accompanied by ulceration (A) and crypt abscesses (B-D). Samples were thus assigned Nancy histological index grades 4 (A) and 3 (B-D). Scale bar, 100 mm. A and B: Mayo endoscopic subscore (MES) grade 0; C: MES grade 1; D: MES grade 2.