Gastrointestinal histoplasmosis complicating pediatric Crohn disease: A case report and review of literature

Figure 1 Colonoscopy findings. Diffuse and severe inflammation characterized by mucosal edema, erythema, friability, pseudopolyps, and serpentine ulcerations. A: Terminal ileum; B: Ileocecal valve; C: Transverse colon; D and E: Descending colon; F: Ascending colon.

Figure 2 Histologic findings. A: Colon biopsy revealed diffuse cellular infiltrate within the lamina propria (hematoxlyin and eosin, × 2, scale bar 1 mm); B: Scattered poorly formed granulomas (arrows) (hematoxlyin and eosin, × 20, scale bar 100 μm); C: Intracellular microorganisms (arrows) (hematoxlyin and eosin, × 40, scale bar 50 μm); Numerous yeast forms suggestive of Histoplasma spp. confirmed by special stains; D: Grocott-Gomori’s Methenamine Silver stain (× 20, scale bar 100 μm); E: Periodic acid Schiff stain (× 20, scale bar 100 μm).