Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt

Table 1 Characteristics of patients with hematological malignant disease included in the study n (%)

Characteristic	Total (n = 165)
Age (mean ± SD)	36.1 ± 23.1
Gender (M)	89 (55.6)
ALT (mean ± SD)	29.7 ± 32.8
AST (mean ± SD)	38.2 ± 49.2
Anti-HCV(+)	39 (23.6)
HBsAg(+)	13 (7.9)
Anti-HBc(+)/HBsAg(-)	54 (32.7)
Clinical characteristics
Malignant lymphoma	88 (53.3)
Hodgkin’s disease	8 (4.8)
Acute leukemia	43 (26.1)
Chronic leukemia	23 (13.9)
Multiple myeloma	3 (1.8)
Steroid containing treatment	110 (66.7)

ALT: Alanine transaminase; AST: Aspartate aminotransferase; HBsAg: Hepatitis B surface antibody; HBc: Hepatitis B virus core; M: Male.

Table 2 Clinical characteristics of patients with occult hepatitis B and detectable full hepatitis B virus genome

Sample ID	Age	Gender	Diagnosis	Anti-HBs (mIU/L)	HBV DNA Log (copies/mL)	Mutation1
EGL6	38	M	Malignant lymphoma	(+)/15	3.5	-
U31	55	F	Malignant lymphoma	(-)	3.8	S143L
EGL4	80	F	Malignant lymphoma	(+)/18.9	2.4	P120S, S143L
A79	5	M	ALL	NT	4.4	P120T
D1	70	M	Malignant lymphoma	(-)	3.9	P120T
D14	5	M	HD	(-)	3.6	P120T

¹Mutation in the “a” determinant region of the S gene product. ALL: Acute lymphoblastic leukemia; HD: Hodgkin disease; HBV: Hepatitis B virus; NT: Not tested; M: Male; F: Female.