Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

Table 1 Clinical background of the patients who provided the human specimens

Patient	Gender	Age (yr)	Primary tumor site	Surgery
1	F	74	Rectum	Ex Rt
2	F	57	Rectum	Ex Rt
3	M	76	Cecum	Ex Rt
4	M	43	S/C	Ex Rt
5	M	56	Rectum	Ex Rt
6	M	53	Rectum	Ex Rt
				+ nonAnat S3
7	F	47	S/C	Ex Rt
8	F	61	Rectum	Ex Rt
9	F	64	S/C	Ex Rt
10	F	63	Rectum	Ex Rt
				+ nonAnat S3

All patients underwent right-sided percutaneous transhepatic portal embolization. F: Female; M: Male; S/C: Sigmoid colon; Ex Rt: Extended right hemilobectomy; nonAnat S3: Non-anatomical liver resection of segment 3.

Table 2 Comparison of the results for pigs and humans

	Pig liver specimens at week 4	Human liver specimens resected around week 4
PV-CV distance	EMB < Cont	EMB < nonEMB
Hepatocyte density	EMB > Cont	EMB > nonEMB
TUNEL-positive cells	EMB > Cont	EMB > nonEMB
LC3 Intensity	N.S.D.	N.S.D.
GS zonation	EMB narrower than Cont	EMB narrower than nonEMB
CYP2E1 zonation	EMB narrower than Cont	EMB narrower than nonEMB

PV-CV: Portal vein to central vein; EMB: Embolized lobe; Cont: Control lobe; nonEMB: Nonembolized lobe; N.S.D: No significant difference.