Scappaticci GB, Regal RE. Cockcroft-Gault revisited: New de-liver-ance on recommendations for use in cirrhosis. World J Hepatol 2017; 9(3): 131-138 [PMID: 28217249 DOI: 10.4254/wjh.v9.i3.131]
Corresponding Author of This Article
Gianni B Scappaticci, PharmD, PGY1 Pharmacy Resident/Adjunct Clinical Instructor, Department of Pharmacy Services, University of Michigan Health System and College of Pharmacy, 1111 E. Catherine Street, Ann Arbor, MI 48109-2054, United States. firstname.lastname@example.org
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World J Hepatol. Jan 28, 2017; 9(3): 131-138 Published online Jan 28, 2017. doi: 10.4254/wjh.v9.i3.131
Table 1 Different methods of estimating creatinine-clearance (A): Equations I-IV were evaluated in the original Cockcroft-Gault study, Equation V is a modified Cockcroft-Gault that only incorporates age and serum creatinine into the equation; B: Different body weight equations tested in the Cockcroft-Gault equation to compensate for various body types
1CrCl × (1.73 m2/BSA) to normalize to body surface area (BSA) of 1.73 m2;
20.3 for 30% ABW and 0.4 for 40% ABW. AdjBW: Adjusted body weight; BMI: Body mass index; CrCl: Creatinine clearance; FFW: Fat free weight; IBW: Ideal body weight; LBW: Lean body weight; SCr: Serum creatinine; TBW: Total body weight; BIA: Bioelectrical impedance analysis.
Table 2 Estimating creatinine clearance in morbidly obese patients by Demirovic et al showed that using fat free weight and lean body weight provided the closest estimate to the control 24-h urine creatinine clearance
1All weight variables used in CG equation only. MDRD4: 186 × SCr-1.154× age-0.203× (0.742 if female) × (1.210 if black); Salazar-Corcoran: Male: (137 - age) × [(0.285 × Wt) + (12.1 × height meters)2], 51 × SCr; Female: (146 - age) × [(0.287 × Wt) + (9.74 × height meters)2], 60 × SCr; ActBW: Actual body weight; AdjBW0.3: 30% adjusted body weight; AdjBW0.4: 40% adjusted body weight; CG: Cockcroft-Gault; CrCl: Creatinine clearance; FFW: Fat free weight; IBW: Ideal body weight; LBW: Lean body weight; MDRD: Modification of diet in renal disease study equation; SD: Standard deviation; Wt: Weight.
Table 3 Results from Dooley et al illustrated that rounding of serum creatinine to 0.6 mg/dL underestimated creatinine clearance by 7%; of note, the majority of clinicians round low serum creatinine values to 0.8 or 1.0 mg/dL