Prospective Study
Copyright ©The Author(s) 2017.
World J Hepatol. Jul 8, 2017; 9(19): 857-866
Published online Jul 8, 2017. doi: 10.4254/wjh.v9.i19.857
Table 1 General and echocardiographic characteristics of the study population with and without hepatic steatosis at baseline n (%)
No/one criterion for hepatic steatosisUS+ and ALT+P-value
n = 1106n = 192
Age (yr), M (SD)59.6 (8.8)57.2 (7.8)P < 0.01
Male gender442 (40.0)139 (72.4)P < 0.001
School educationn.s.
< 10 yr570 (51.5)102 (53.1)
10 yr358 (32.4)67 (34.9)
> 10 yr178 (16.1)23 (12.0)
Waist circumference (cm), M (SD)89.0 (11.5)100.8 (10.9)P < 0.001
Body weight (kg), M (SD)75.6 (12.8)88.6 (13.9)P < 0.001
BMI, (kg/m2), M (SD)27.4 (4.3)30.5 (4.6)P < 0.001
SmokingP < 0.001
Never-smoker516 (46.6)57 (29.7)
Ex-smoker382 (34.5)99 (51.7)
Current smoker208 (18.8)36 (18.8)
Alcohol consumption (g/d), M (SD)9.1 (14.5)15.6 (19.5)P < 0.001
Diabetes mellitus100 (9.0)26 (13.5)P < 0.001
Systolic blood pressure (mmHg), M (SD)139.3 (20.2)148.5 (17.4)P < 0.001
Diastolic blood pressure (mmHg), M (SD)84.7 (10.8)89.9 (10.4)P < 0.001
Pulse pressure (mmHg), M (SD)54.6 (14.7)58.6 (13.4)P < 0.01
Hypertension660 (59.7)163 (84.9)P < 0.001
Intake of drugs with ATC07239 (21.6)39 (20.3)n.s.
Intake of drugs with ATC08140 (12.7)28 (14.6)n.s.
Intake of drugs with ATC09198 (17.9)58 (30.2)P < 0.001
IVS, M (SD)9.7 (2.2)10.9 (2.5)P < 0.001
LVEDD, M (SD)50.9 (5.6)52.4 (5.9)P < 0.01
PWD, M (SD)9.6 (1.9)10.4 (2.0)P < 0.001
LVM (g), M (SD)181.8 (53.5)215.8 (61.3)P < 0.001
LVMI (g/m2.7), M (SD)46.2 (13.3)51.0 (13.7)P < 0.001
LVH499 (45.1)114 (59.4)P < 0.001
Table 2 Echocardiographic characteristics and blood pressure at baseline and follow-up in the study population with and without hepatic steatosis
BaselineFollow-upP-value
M (SD)M (SD)
IVS, M (SD)
No/one criterion for hepatic steatosis9.7 (2.2)11.2 (2.7)P < 0.001
US+ and ALT+10.9 (2.5)12.0 (2.9)P < 0.001
LVEDD, M (SD)
No/one criterion for hepatic steatosis50.9 (5.6)48.8 (5.5)P < 0.001
US+ and ALT+52.4 (5.9)50.6 (5.3)P < 0.001
PWD, M (SD)
No/one criterion for hepatic steatosis9.6 (1.9)9.9 (1.9)P < 0.001
US+ and ALT+10.4 (2.0)10.9 (2.1)P < 0.01
LVM (g), M (SD)
No/one criterion for hepatic steatosis181.8 (53.5)192.2 (56.8)P < 0.001
US+ and ALT+215.8 (61.3)226.1 (62.4)P < 0.01
LVMI (g/m2.7), M(SD)
No/one criterion for hepatic steatosis46.2 (13.3)49.2 (14.6)P < 0.001
US+ and ALT+51.0 (13.7)53.7 (14.4)P < 0.01
SBP (mmHg), M (SD)
No/one criterion for hepatic steatosis139.3 (20.2)136.3 (19.2)P < 0.001
US+ and ALT+148.5 (17.4)142.8 (19.0)P < 0.001
DBP (mmHg), M (SD)
No/one criterion for hepatic steatosis84.7 (10.8)81.2 (10.3)P < 0.001
US+ and ALT+89.9 (10.4)85.0 (11.1)P < 0.001
LVH
No/one criterion for hepatic steatosis499 (45.1)597 (54.0)P < 0.001
US+ and ALT+114 (59.4)128 (66.7)P < 0.001
Hypertension
No/one criterion for hepatic steatosis660 (59.7)686 (62.0)P < 0.001
US+ and ALT+163 (84.9)154 (80.2)P < 0.001
Table 3 Bivariate Pearson correlations
SexAgeFLDLVMIt0LVMIt1SBPt0SBPt1DBPt0
Sex
Age-0.04
FLD-0.23b-0.10b
LVMIt0-0.12b0.30b0.13b
LVMIt1-0.08b0.26b0.11b0.62b
SBPt0-0.21b0.24b0.16b0.36b0.24b
SBPt1-0.13b0.18b0.12b0.22b0.22b0.49b
DBPt0-0.20b-0.14b0.17b0.19b0.11b0.71b0.32b
DBPt1-0.15b-0.28b0.13b0.040.050.28b0.65b0.52b