Jeffrey AW, Huang Y, de Boer WB, Adams LA, MacQuillan G, Speers D, Joseph J, Jeffrey GP. Improved Hepascore in hepatitis C predicts reversal in risk of adverse outcome. World J Hepatol 2017; 9(19): 850-856 [PMID: 28740596 DOI: 10.4254/wjh.v9.i19.850]
Corresponding Author of This Article
Dr. Angus W Jeffrey, School of Medicine, University of Notre Dame, 32 Mouat St, Fremantle, WA 6160, Australia. angus.jeffrey1@my.nd.edu.au
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 2 Predictors of composite clinical endpoint (liver related death, hepatocellular carcinoma, liver decompensation) using Multivariate Cox Regression
Variable
Follow-up from the baseline Hepascore
Follow-up from the second Hepascore
P
Hazard ratio (95%CI)
P
Hazard ratio (95%CI)
Baseline Hepascore
< 0.001
5.85 (2.25-15.18)
0.020
12.86 (1.49-111.17)
Second Hepascore
-
-
0.891
3288.82 (0.0-4.6E + 53)
Delta Hepascore
-
-
0.013
4.77 (1.35-16.45)
Table 3 Predictors of survival using Kaplan-Meier survival curves
Test
End point
P value (log rank)
Cohort size
Baseline Hepascore alone
Composite Endpoint
< 0.001
346
LRD
< 0.001
352
LD
< 0.001
348
HCC
< 0.001
350
Delta Hepascore
Composite Endpoint
0.004
96
LRD
0.048
105
LD
0.001
101
HCC
0.178
100
Table 4 Predictors of survival Using Area under Receiver Operating Characteristic
Test
End point
AUROC
Baseline Hepascore alone
Composite endpoint
0.80
LRD
0.89
LD
0.75
HCC
0.87
Baseline Hepascore > 0.75 and Delta Hepascore
Composite endpoint
0.84
LRD
0.95
LD
0.77
HCC
0.93
Citation: Jeffrey AW, Huang Y, de Boer WB, Adams LA, MacQuillan G, Speers D, Joseph J, Jeffrey GP. Improved Hepascore in hepatitis C predicts reversal in risk of adverse outcome. World J Hepatol 2017; 9(19): 850-856