Angiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats

Table 1 Serum parameters and glycogen content

Group	Glycemia (mg/dL)	n	Insulinemia (ng/mL)	n	Glycogen content (mg/100 mg liver)	n
WIS	75.4 ± 4.2	9	2.1 ± 0.4	12	2.9 ± 0.2	10
L-NAME	80.7 ± 7.5	8	2.0 ± 0.4	12	2.3 ± 0.2	10
WKY	76.9 ± 4.0	9	3.8 ± 0.6	12	2.8 ± 0.2	10
SHR	86.2 ± 4.0	8	2.7 ± 0.4	13	2.8 ± 0.2	10

Serum and liver fragment for glycogen content measurement were collected before the liver perfusion experiment. Values are expressed as mean ± SEM. Student’s t-test; L-NAME vs WIS and SHR vs WKY. WIS: Similar to normal rats; SHR: Spontaneously hypertensive rat; WKY: Wistar Kyoto.

Table 2 Glucose release induced by angiotensinII or epinephrine

	Glucose released μmol/min.g liver
Group	Angiotensin II	n	Epinephrine	n
WIS	11.3 ± 0.9	7	7.5 ± 0.9	10
L-NAME	11.2 ± 1.5	7	4.2 ± 0.4d	8
WKY	16.4 ± 1.5	7	8.0 ± 0.9	8
SHR	5.42 ± 0.6b	10	5.9 ± 0.7	6

The amount of glucose (area under the curve) was calculated from the curve glucose release increase vs time after agonist injection. Student’s t-test;

^bP < 0.0001 and

^dP = 0.002 compared with respective control (L-NAME vs WIS and SHR vs WKY). WIS: Similar to normal rats; SHR: Spontaneously hypertensive rat; WKY: Wistar Kyoto.

Table 3 Portal hypertensive response to angiotensinII or epinephrine

	Portal hypertensive response cmH2O.min
Group	Angiotensin II	n	Epinephrine	n
WIS	26.4 ± 3.2	7	8.2 ± 0.8	10
L-NAME	38.1 ± 4.8	7	18.5 ± 1.9b	8
WKY	29.0 ± 1.1	7	10.0 ± 1.1	8
SHR	25.9 ± 3.7	10	10.5 ± 1.1	6

The portal hypertensive response (PHR; area under the curve) was calculated from portal pressure increase curve vs time after agonist injection and expressed as cmH₂O.min. Student’s t-test;

^bP < 0.0001 compared with respective control (L-NAME vs WIS and SHR vs WKY). WIS: Similar to normal rats; SHR: Spontaneously hypertensive rat; WKY: Wistar Kyoto.